Distribution of cervical intraepithelial neoplasia across the cervix is random

Samuel Lurie, Miri Eliaz, Mona Boaz, Tally Levy, Abraham Golan, Oscar Sadan

Research output: Contribution to journalArticlepeer-review


Objective: This study was undertaken to assess the validity of an assumption that histologically confirmed cervical intraepithelial neoplasia (CIN) lesions are not randomly distributed across the cervix. Study design: This retrospective study included 359 women ranging in age from 17-81 years (mean ± SD, 34.4 ± 12.1 years) who underwent colposcopically directed cervical biopsy. Data were examined to determine the distribution of histologic diagnosis across the cervix. The study had 80% power to detect a true, relative by-location difference. Results: Two hundred ninety (80.8%) women were classified as nondysplastic, whereas 69 (19.2%) were classified as dysplastic (CIN1, or CIN2, or CIN3). The most common location for biopsy was the 11 o'clock position (22%), whereas the least common location was the 10 o'clock position (0.8%). The most common location for dysplastic as well as nondysplastic lesion was the 11 o'clock position. No association was found between types of histologic lesion on colposcopically directed biopsy and location of lesion. Conclusion: Contrary to previous assumptions, histologically confirmed CIN lesions are randomly distributed across the cervix site.

Original languageEnglish
Pages (from-to)125.e1-125.e3
JournalAmerican Journal of Obstetrics and Gynecology
Issue number2
StatePublished - Feb 2007


  • cervical intraepithelial neoplasia
  • colposcopy
  • lesion location


Dive into the research topics of 'Distribution of cervical intraepithelial neoplasia across the cervix is random'. Together they form a unique fingerprint.

Cite this