Distribution of actin, myosin and actin binding protein in platelets of patients with hyperlipoproteinemia

A. Eldor*, I. Kahane, S. Yatziv, M. Fainaru, A. Muhlrad

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Significant anomalies in the quantity and relative distribution of the contractile proteins actin, myosin and actin binding protein (ABP) were observed in platelets obtained from patients with hyperbetalipoproteinemia (type IIa) and in patients with hypertriglyceridemia (type IV). Changes were observed in unfractionated platelets, (increased ABP in type IIa patients and increased actin in both type IIa and type IV) in isolated platelet membranes (increased ABP and actin in type IV, and increased myosin in type IIa) and in the KC1 extract of platelets (increased actin in type IV and increased myosin in type IIa). The myosin ATPase specific activity was increased in platelets of type IV patients. No changes were observed in the concentrations and distribution of membrane glycoproteins in the platelets of these patients. The above anomalies in the contractile proteins might be relevant to the known functional anomalies of the platelets of patients with hyperlipoproteinemias.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalThrombosis Research
Volume31
Issue number1
DOIs
StatePublished - 1 Jul 1983
Externally publishedYes

Keywords

  • hyperlipoproteinemia
  • platelet contractile proteins

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