Distribution and localization of a G protein-coupled inwardly rectifying K+ channel in the rat

Christine Karschin; Wolfgang Schreibmayer; Nathan Dascal; Henry Lester; Norman Davidson; Andreas Karschin

doi:10.1016/0014-5793(94)00590-7

Distribution and localization of a G protein-coupled inwardly rectifying K⁺ channel in the rat

Christine Karschin^*
, Wolfgang Schreibmayer
, Nathan Dascal
, Henry Lester
, Norman Davidson
, Andreas Karschin

^*Corresponding author for this work

Max Planck Institute of Experimental Medicine
California Institute of Technology
Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute)

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

The cellular distribution of the mRNA of the inwardly rectifying K⁺ channel KGA (GIRK1) was investigated in rat tissue by in situ hybridization. KGA was originally cloned from the heart and represents the first G protein-activated K⁺ channel identified. It is expressed in peripheral tissue solely in the atrium, but not in the ventricle, skeletal muscle, lung and kidney. In the central nervous system KGA is most prominently expressed in the Ammon's horn and dentate gyrus of the hippocampus, neocortical layers II-VI, cerebellar granular layer, olfactory bulb, anterior pituitary, thalamic nuclei and several distinct nuclei of the lower brainstem. The abundant expression of KGA in many CNS neurons support its important role as a major target channel for G protein mediated receptor function.

Original language	English
Pages (from-to)	139-144
Number of pages	6
Journal	FEBS Letters
Volume	348
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(94)00590-7
State	Published - 11 Jul 1994
Externally published	Yes

Funding

Funders	Funder number
National Institute of Mental Health	P50MH049176
National Institute of General Medical Sciences	R01GM029836

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10.1016/0014-5793(94)00590-7

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title = "Distribution and localization of a G protein-coupled inwardly rectifying K+ channel in the rat",

abstract = "The cellular distribution of the mRNA of the inwardly rectifying K+ channel KGA (GIRK1) was investigated in rat tissue by in situ hybridization. KGA was originally cloned from the heart and represents the first G protein-activated K+ channel identified. It is expressed in peripheral tissue solely in the atrium, but not in the ventricle, skeletal muscle, lung and kidney. In the central nervous system KGA is most prominently expressed in the Ammon's horn and dentate gyrus of the hippocampus, neocortical layers II-VI, cerebellar granular layer, olfactory bulb, anterior pituitary, thalamic nuclei and several distinct nuclei of the lower brainstem. The abundant expression of KGA in many CNS neurons support its important role as a major target channel for G protein mediated receptor function.",

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AU - Karschin, Christine

AU - Schreibmayer, Wolfgang

AU - Dascal, Nathan

AU - Lester, Henry

AU - Davidson, Norman

AU - Karschin, Andreas

PY - 1994/7/11

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N2 - The cellular distribution of the mRNA of the inwardly rectifying K+ channel KGA (GIRK1) was investigated in rat tissue by in situ hybridization. KGA was originally cloned from the heart and represents the first G protein-activated K+ channel identified. It is expressed in peripheral tissue solely in the atrium, but not in the ventricle, skeletal muscle, lung and kidney. In the central nervous system KGA is most prominently expressed in the Ammon's horn and dentate gyrus of the hippocampus, neocortical layers II-VI, cerebellar granular layer, olfactory bulb, anterior pituitary, thalamic nuclei and several distinct nuclei of the lower brainstem. The abundant expression of KGA in many CNS neurons support its important role as a major target channel for G protein mediated receptor function.

AB - The cellular distribution of the mRNA of the inwardly rectifying K+ channel KGA (GIRK1) was investigated in rat tissue by in situ hybridization. KGA was originally cloned from the heart and represents the first G protein-activated K+ channel identified. It is expressed in peripheral tissue solely in the atrium, but not in the ventricle, skeletal muscle, lung and kidney. In the central nervous system KGA is most prominently expressed in the Ammon's horn and dentate gyrus of the hippocampus, neocortical layers II-VI, cerebellar granular layer, olfactory bulb, anterior pituitary, thalamic nuclei and several distinct nuclei of the lower brainstem. The abundant expression of KGA in many CNS neurons support its important role as a major target channel for G protein mediated receptor function.

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Distribution and localization of a G protein-coupled inwardly rectifying K⁺ channel in the rat

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