TY - JOUR
T1 - Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1)
AU - Levi, Maya
AU - Meijler, Michael M.
AU - Gómez-Muñoz, Antonio
AU - Zor, Tsaffrir
PY - 2010/1/27
Y1 - 2010/1/27
N2 - Ceramide-1-phosphate (C1P) is known as a second messenger regulating a multitude of processes including cell growth, apoptosis and inflammation. Exciting recent findings now suggest that C1P can stimulate macrophages migration in an extra-cellular manner via a G protein-coupled receptor (GPCR). Interestingly, a synthetic C1P analog, named phospho-ceramide analogue-1 (PCERA-1), was recently described as a potent in-vivo anti-inflammatory agent, and was suggested to act on macrophages in an extra-cellular manner via a GPCR. Here we summarize and compare the receptor-mediated as well as receptor-independent activities of natural C1P and its synthetic analog. We also provide experimental data in support of distinct C1P and PCERA-1 receptors.
AB - Ceramide-1-phosphate (C1P) is known as a second messenger regulating a multitude of processes including cell growth, apoptosis and inflammation. Exciting recent findings now suggest that C1P can stimulate macrophages migration in an extra-cellular manner via a G protein-coupled receptor (GPCR). Interestingly, a synthetic C1P analog, named phospho-ceramide analogue-1 (PCERA-1), was recently described as a potent in-vivo anti-inflammatory agent, and was suggested to act on macrophages in an extra-cellular manner via a GPCR. Here we summarize and compare the receptor-mediated as well as receptor-independent activities of natural C1P and its synthetic analog. We also provide experimental data in support of distinct C1P and PCERA-1 receptors.
KW - C1P
KW - Cell migration
KW - Inflammation
KW - Macrophages
KW - PCERA-1
KW - Phospholipid-binding receptors
UR - http://www.scopus.com/inward/record.url?scp=71849107705&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2009.05.007
DO - 10.1016/j.mce.2009.05.007
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AN - SCOPUS:71849107705
SN - 0303-7207
VL - 314
SP - 248
EP - 255
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 2
ER -
