@article{3ad7f6e2820a4104b54591e1f4f16ea8,
title = "Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities",
abstract = "Cardiovascular ageing contributes to cognitive impairment. However, the unique and synergistic contributions of multiple cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or examined in isolation. We hypothesized that vascular risk factors, electrocardiographic features and blood pressure indices reveal multiple latent vascular factors, with independent contributions to cognition. In a population-based deep-phenotyping study (n = 708, age 18–88), path analysis revealed three latent vascular factors dissociating the autonomic nervous system response from two components of blood pressure. These three factors made unique and additive contributions to the variability in crystallized and fluid intelligence. The discrepancy in fluid relative to crystallized intelligence, indicative of cognitive decline, was associated with a latent vascular factor predominantly expressing pulse pressure. This suggests that higher pulse pressure is associated with cognitive decline from expected performance. The effect was stronger in older adults. Controlling pulse pressure may help to preserve cognition, particularly in older adults. Our findings highlight the need to better understand the multifactorial nature of vascular aging.",
author = "Cam-CAN and King, {Deborah L.O.} and Henson, {Richard N.} and Rogier Kievit and Noham Wolpe and Carol Brayne and Tyler, {Lorraine K.} and Rowe, {James B.} and Bullmore, {Edward T.} and Calder, {Andrew C.} and Rhodri Cusack and Tim Dalgleish and John Duncan and Matthews, {Fiona E.} and Marslen-Wilson, {William D.} and Shafto, {Meredith A.} and Karen Campbell and Teresa Cheung and Simon Davis and Linda Geerligs and Anna McCarrey and Abdur Mustafa and Darren Price and David Samu and Taylor, {Jason R.} and Matthias Treder and {van Belle}, Janna and Nitin Williams and Daniel Mitchell and Simon Fisher and Else Eising and Ethan Knights and Lauren Bates and Tina Emery and Sharon Erzin{\c c}lioglu and Andrew Gadie and Sofia Gerbase and Stanimira Georgieva and Claire Hanley and Beth Parkin and David Troy and Tibor Auer and Marta Correia and Lu Gao and Emma Green and Rafael Henriques and Jodie Allen and Gillian Amery and Liana Amuntse and Anne Barcroft and Amanda Castle",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = dec,
doi = "10.1038/s41598-022-27252-1",
language = "אנגלית",
volume = "13",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Research",
number = "1",
}