Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters

Burçin Acar; Jessica Rose; Burcu Aykac Fas; Nir Ben-Tal; Oded Lewinson; Turkan Haliloglu

doi:10.1016/j.str.2020.03.014

Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters

Burçin Acar, Jessica Rose, Burcu Aykac Fas, Nir Ben-Tal, Oded Lewinson^*, Turkan Haliloglu

^*Corresponding author for this work

Biochemistry Molecular Biology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Long-range allosteric communication are essential to the function of molecular machines. Here, Acar et al. studied long-range communications in ABC transporters, and discovered that, despite the similar architecture of the transporters, each uses a very different communications network that is fine-tuned to its specific physiological role.

Original language	English
Pages (from-to)	651-663.e5
Journal	Structure
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/j.str.2020.03.014
State	Published - 2 Jun 2020

Keywords

ABC transporter
ANM
ANM-LD
ATP hydrolysis
allostery
membrane protein
molecular dynamics
transport

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10.1016/j.str.2020.03.014

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AU - Haliloglu, Turkan

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Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters

Abstract

Keywords

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