Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters

Burçin Acar, Jessica Rose, Burcu Aykac Fas, Nir Ben-Tal, Oded Lewinson*, Turkan Haliloglu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Long-range allosteric communication are essential to the function of molecular machines. Here, Acar et al. studied long-range communications in ABC transporters, and discovered that, despite the similar architecture of the transporters, each uses a very different communications network that is fine-tuned to its specific physiological role.

Original languageEnglish
Pages (from-to)651-663.e5
JournalStructure
Volume28
Issue number6
DOIs
StatePublished - 2 Jun 2020

Funding

FundersFunder number
Israeli Academy of Sciences1006/18
NATO Science for Peace and Security Program
Rappaport Family Institute
United States-Israel Binational Science Foundation2015102
Saudi Pharmaceutical SocietyG4622
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu115M418
Boğaziçi Üniversitesi11160

    Keywords

    • ABC transporter
    • ANM
    • ANM-LD
    • ATP hydrolysis
    • allostery
    • membrane protein
    • molecular dynamics
    • transport

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