Dissociation between sleep-related and TRH-induced prolactin secretion in seminiferous tubule failure

I. M. Spitz; P. Lavie; N. Calderon; C. R. Gordon; A. Oksenberg; M. Ron; N. Laufer; Y. Livshin; J. Schenker

doi:10.1016/0026-0495(82)90020-8

Dissociation between sleep-related and TRH-induced prolactin secretion in seminiferous tubule failure

I. M. Spitz^*
, P. Lavie
, N. Calderon
, C. R. Gordon
, A. Oksenberg
, M. Ron
, N. Laufer
, Y. Livshin
, J. Schenker

^*Corresponding author for this work

Hadassah University Medical Centre

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Prolactin (PRL) secretion has been measured during sleep and following TRH administration in 8 patients aged 24-39 yr with seminiferous tubule failure and 36 controls. Basal LH levels were 25.7 ± 14.7 mIU/ml in the patients compared to 11.5 ± 4.2 mlU/ml in the controls (p < 0.01). Corresponding FSH levels were 26.2 ± 10.7 mIU/ml and 5.9 ± 2.1 mIU/ml (p < 0.001). Mean estradiol 17B and testosterone levels were similar in the 2 groups. The mean PRL secretion during sleep was 16.5 ± 11.7 ng/ml in the patients and not different in 11 of the controls (12.4 ± 3.2 ng/ml). One patient had a mean nocturnal PRL concentration of 44.1 ng/ml. In both groups, the mean sleep related PRL concentration was greater than that during waking hours. The average number of peaks in the 2 groups was similar. In the same patients, the peak PRL response to TRH (200 ug IV) was 81.9 ± 18.8 ng/ml as compared to 32.1 ± 10.7 ng/ml in the controls (p < 0.001). It is concluded that PRL concentrations following pharmacological stimulation are increased in seminiferous tubule failure, whereas levels are normal in relation to the physiological stimulus of sleep.

Original language	English
Pages (from-to)	10-13
Number of pages	4
Journal	Metabolism: Clinical and Experimental
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/0026-0495(82)90020-8
State	Published - Jan 1982
Externally published	Yes

Funding

Funders
Wolinsky Bessin Research Fund
Ministry of Health, State of Israel

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10.1016/0026-0495(82)90020-8

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@article{d0ac3a4ad554484ea2f77758aa1540c5,

title = "Dissociation between sleep-related and TRH-induced prolactin secretion in seminiferous tubule failure",

abstract = "Prolactin (PRL) secretion has been measured during sleep and following TRH administration in 8 patients aged 24-39 yr with seminiferous tubule failure and 36 controls. Basal LH levels were 25.7 ± 14.7 mIU/ml in the patients compared to 11.5 ± 4.2 mlU/ml in the controls (p < 0.01). Corresponding FSH levels were 26.2 ± 10.7 mIU/ml and 5.9 ± 2.1 mIU/ml (p < 0.001). Mean estradiol 17B and testosterone levels were similar in the 2 groups. The mean PRL secretion during sleep was 16.5 ± 11.7 ng/ml in the patients and not different in 11 of the controls (12.4 ± 3.2 ng/ml). One patient had a mean nocturnal PRL concentration of 44.1 ng/ml. In both groups, the mean sleep related PRL concentration was greater than that during waking hours. The average number of peaks in the 2 groups was similar. In the same patients, the peak PRL response to TRH (200 ug IV) was 81.9 ± 18.8 ng/ml as compared to 32.1 ± 10.7 ng/ml in the controls (p < 0.001). It is concluded that PRL concentrations following pharmacological stimulation are increased in seminiferous tubule failure, whereas levels are normal in relation to the physiological stimulus of sleep.",

author = "Spitz, \{I. M.\} and P. Lavie and N. Calderon and Gordon, \{C. R.\} and A. Oksenberg and M. Ron and N. Laufer and Y. Livshin and J. Schenker",

note = "Funding Information: From the Department of Endocrinology and Metabolism, Shaare Zedek Medical Center, Jerusalem, Sleep Laboratory, Faculty of Medicine, Technion, Haifa, and Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel. Received for publication November 24, 1980. Supported by grants to IMS from the Chief Scientist's Office, Ministry of Health, Israel, and the Wolinsky Bessin Research Fund, Toronto, Canada. Address reprint requests to L M. Spitz, MD, Department of Endocrinology and Metabolism, Shaare Zedek Medical Center, Box 293, Jerusalem 91 000, Israel. {\textcopyright} 1982 by Grune \& Stratton, Inc. 0026-0495/82/3101-0003501.00/0",

year = "1982",

month = jan,

doi = "10.1016/0026-0495(82)90020-8",

language = "אנגלית",

volume = "31",

pages = "10--13",

journal = "Metabolism: Clinical and Experimental",

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T1 - Dissociation between sleep-related and TRH-induced prolactin secretion in seminiferous tubule failure

AU - Spitz, I. M.

AU - Lavie, P.

AU - Calderon, N.

AU - Gordon, C. R.

AU - Oksenberg, A.

AU - Ron, M.

AU - Laufer, N.

AU - Livshin, Y.

AU - Schenker, J.

N1 - Funding Information: From the Department of Endocrinology and Metabolism, Shaare Zedek Medical Center, Jerusalem, Sleep Laboratory, Faculty of Medicine, Technion, Haifa, and Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel. Received for publication November 24, 1980. Supported by grants to IMS from the Chief Scientist's Office, Ministry of Health, Israel, and the Wolinsky Bessin Research Fund, Toronto, Canada. Address reprint requests to L M. Spitz, MD, Department of Endocrinology and Metabolism, Shaare Zedek Medical Center, Box 293, Jerusalem 91 000, Israel. © 1982 by Grune & Stratton, Inc. 0026-0495/82/3101-0003501.00/0

PY - 1982/1

Y1 - 1982/1

N2 - Prolactin (PRL) secretion has been measured during sleep and following TRH administration in 8 patients aged 24-39 yr with seminiferous tubule failure and 36 controls. Basal LH levels were 25.7 ± 14.7 mIU/ml in the patients compared to 11.5 ± 4.2 mlU/ml in the controls (p < 0.01). Corresponding FSH levels were 26.2 ± 10.7 mIU/ml and 5.9 ± 2.1 mIU/ml (p < 0.001). Mean estradiol 17B and testosterone levels were similar in the 2 groups. The mean PRL secretion during sleep was 16.5 ± 11.7 ng/ml in the patients and not different in 11 of the controls (12.4 ± 3.2 ng/ml). One patient had a mean nocturnal PRL concentration of 44.1 ng/ml. In both groups, the mean sleep related PRL concentration was greater than that during waking hours. The average number of peaks in the 2 groups was similar. In the same patients, the peak PRL response to TRH (200 ug IV) was 81.9 ± 18.8 ng/ml as compared to 32.1 ± 10.7 ng/ml in the controls (p < 0.001). It is concluded that PRL concentrations following pharmacological stimulation are increased in seminiferous tubule failure, whereas levels are normal in relation to the physiological stimulus of sleep.

AB - Prolactin (PRL) secretion has been measured during sleep and following TRH administration in 8 patients aged 24-39 yr with seminiferous tubule failure and 36 controls. Basal LH levels were 25.7 ± 14.7 mIU/ml in the patients compared to 11.5 ± 4.2 mlU/ml in the controls (p < 0.01). Corresponding FSH levels were 26.2 ± 10.7 mIU/ml and 5.9 ± 2.1 mIU/ml (p < 0.001). Mean estradiol 17B and testosterone levels were similar in the 2 groups. The mean PRL secretion during sleep was 16.5 ± 11.7 ng/ml in the patients and not different in 11 of the controls (12.4 ± 3.2 ng/ml). One patient had a mean nocturnal PRL concentration of 44.1 ng/ml. In both groups, the mean sleep related PRL concentration was greater than that during waking hours. The average number of peaks in the 2 groups was similar. In the same patients, the peak PRL response to TRH (200 ug IV) was 81.9 ± 18.8 ng/ml as compared to 32.1 ± 10.7 ng/ml in the controls (p < 0.001). It is concluded that PRL concentrations following pharmacological stimulation are increased in seminiferous tubule failure, whereas levels are normal in relation to the physiological stimulus of sleep.

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Dissociation between sleep-related and TRH-induced prolactin secretion in seminiferous tubule failure

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