TY - JOUR
T1 - Disseminated dermatophytic pseudomycetoma caused by Microsporum species
AU - Tirado-González, Mariantonieta
AU - Ball, Elizabeth
AU - Ruiz, Angela
AU - Rodriguez, Ysabel
AU - Goudet, Carmen Elena
AU - Finkel, Oksana
AU - Golan, Haim
AU - de Morentin, Helena Martinez
AU - Sprecher, Hanna
AU - Sprecher, Eli
AU - Gat, Andrea
PY - 2012/12
Y1 - 2012/12
N2 - Background Dermatophyte infection is almost exclusively a superficial cutaneous mycosis usually confined to the stratum corneum of nails and hairs of normal hosts. Deep cutaneous and subcutaneous infections due to dermatophytes are exceedingly rare and usually limited to immunosuppressed individuals. These infections remain chronic and persist in spite of treatment. Materials and methods We report two clinical cases of disseminated dermatophytic pseudomycetoma caused by Microsporum gypseum and Microsporum canis in immunosuppressed patients. Results Patient 1, in 2008, showed improvement with fluconazole, cephalothin, and terbinafine treatment for Microsporum gypseum. After suspension of the treatment, new lesions appeared and culture from material was positive. In 2009, she presented confluent papules and nodules forming plaques on her face and neck with the isolation of Microsporum canis. Clinical response to this treatment was poor. Patient 2 was affected by both tinea corporis due to Trichophyton rubrum and dermatophytic pseudomycetoma caused by Microsporum canis. The response to treatment was successful with oral itraconazole and local surgical excision. Conclusions It is important to recognize these atypical presentations of dermatophytic infections in immunosuppressed patients, which may warrant a more aggressive treatment in order to achieve resolution.
AB - Background Dermatophyte infection is almost exclusively a superficial cutaneous mycosis usually confined to the stratum corneum of nails and hairs of normal hosts. Deep cutaneous and subcutaneous infections due to dermatophytes are exceedingly rare and usually limited to immunosuppressed individuals. These infections remain chronic and persist in spite of treatment. Materials and methods We report two clinical cases of disseminated dermatophytic pseudomycetoma caused by Microsporum gypseum and Microsporum canis in immunosuppressed patients. Results Patient 1, in 2008, showed improvement with fluconazole, cephalothin, and terbinafine treatment for Microsporum gypseum. After suspension of the treatment, new lesions appeared and culture from material was positive. In 2009, she presented confluent papules and nodules forming plaques on her face and neck with the isolation of Microsporum canis. Clinical response to this treatment was poor. Patient 2 was affected by both tinea corporis due to Trichophyton rubrum and dermatophytic pseudomycetoma caused by Microsporum canis. The response to treatment was successful with oral itraconazole and local surgical excision. Conclusions It is important to recognize these atypical presentations of dermatophytic infections in immunosuppressed patients, which may warrant a more aggressive treatment in order to achieve resolution.
UR - http://www.scopus.com/inward/record.url?scp=84869852020&partnerID=8YFLogxK
U2 - 10.1111/j.1365-4632.2012.05550.x
DO - 10.1111/j.1365-4632.2012.05550.x
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C2 - 23171014
AN - SCOPUS:84869852020
SN - 0011-9059
VL - 51
SP - 1478
EP - 1482
JO - International Journal of Dermatology
JF - International Journal of Dermatology
IS - 12
ER -