Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics

Weining Zhang; Bruno Pouzet; Ana L. Jongen-Rêlo; Ina Weiner; Joram Feldon

doi:10.1097/00001756-199908200-00018

Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics

Weining Zhang, Bruno Pouzet, Ana L. Jongen-Rêlo, Ina Weiner, Joram Feldon

School of Psychological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The present study tested the effects of the typical neuroleptic haloperidol and an atypical neuroleptic clozapine on ventral hippocampus stimulation-induced disruption of prepulse inhibition (PPI). Bilateral infusions of 0.7 μg NMDA into the ventral hippocampus disrupted PPI. The impairment of PPI following the infusion was completely normalized 24h after the infusion. This disruption of PPI was antagonized by clozapine (5.0 mg/kg), but not by haloperidol (0.2 mg/kg). Since disruption of PPI is considered to constitute an animal model of schizophrenia that is related to the deficit of sensorimotor gating observed in schizophrenic patients, these results suggest that PPI disruption induced by intra-ventral hippocampal infusions of NMDA may serve as an animal model for the selective detection of atypical antipsychotics.

Original language	English
Pages (from-to)	2533-2538
Number of pages	6
Journal	NeuroReport
Volume	10
Issue number	12
DOIs	https://doi.org/10.1097/00001756-199908200-00018
State	Published - 20 Aug 1999

Keywords

Animal model
Antipsychotics
Clozapine
Haloperidol
NMDA
Neuroleptics
Prepulse inhibition
Ventral hippocampus

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Zhang, W., Pouzet, B., Jongen-Rêlo, A. L., Weiner, I., & Feldon, J. (1999). Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics. NeuroReport, 10(12), 2533-2538. https://doi.org/10.1097/00001756-199908200-00018

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title = "Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics",

abstract = "The present study tested the effects of the typical neuroleptic haloperidol and an atypical neuroleptic clozapine on ventral hippocampus stimulation-induced disruption of prepulse inhibition (PPI). Bilateral infusions of 0.7 μg NMDA into the ventral hippocampus disrupted PPI. The impairment of PPI following the infusion was completely normalized 24h after the infusion. This disruption of PPI was antagonized by clozapine (5.0 mg/kg), but not by haloperidol (0.2 mg/kg). Since disruption of PPI is considered to constitute an animal model of schizophrenia that is related to the deficit of sensorimotor gating observed in schizophrenic patients, these results suggest that PPI disruption induced by intra-ventral hippocampal infusions of NMDA may serve as an animal model for the selective detection of atypical antipsychotics.",

keywords = "Animal model, Antipsychotics, Clozapine, Haloperidol, NMDA, Neuroleptics, Prepulse inhibition, Ventral hippocampus",

author = "Weining Zhang and Bruno Pouzet and Jongen-R{\^e}lo, {Ana L.} and Ina Weiner and Joram Feldon",

year = "1999",

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doi = "10.1097/00001756-199908200-00018",

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Zhang, W, Pouzet, B, Jongen-Rêlo, AL, Weiner, I & Feldon, J 1999, 'Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics', NeuroReport, vol. 10, no. 12, pp. 2533-2538. https://doi.org/10.1097/00001756-199908200-00018

Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol : A possible model for the screening of atypical antipsychotics. / Zhang, Weining; Pouzet, Bruno; Jongen-Rêlo, Ana L.; Weiner, Ina ; Feldon, Joram.

In: NeuroReport, Vol. 10, No. 12, 20.08.1999, p. 2533-2538.

Research output: Contribution to journal › Article › peer-review

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Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics

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