Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics

Weining Zhang, Bruno Pouzet, Ana L. Jongen-Rêlo, Ina Weiner, Joram Feldon

Research output: Contribution to journalArticlepeer-review

Abstract

The present study tested the effects of the typical neuroleptic haloperidol and an atypical neuroleptic clozapine on ventral hippocampus stimulation-induced disruption of prepulse inhibition (PPI). Bilateral infusions of 0.7 μg NMDA into the ventral hippocampus disrupted PPI. The impairment of PPI following the infusion was completely normalized 24h after the infusion. This disruption of PPI was antagonized by clozapine (5.0 mg/kg), but not by haloperidol (0.2 mg/kg). Since disruption of PPI is considered to constitute an animal model of schizophrenia that is related to the deficit of sensorimotor gating observed in schizophrenic patients, these results suggest that PPI disruption induced by intra-ventral hippocampal infusions of NMDA may serve as an animal model for the selective detection of atypical antipsychotics.

Original languageEnglish
Pages (from-to)2533-2538
Number of pages6
JournalNeuroReport
Volume10
Issue number12
DOIs
StatePublished - 20 Aug 1999

Keywords

  • Animal model
  • Antipsychotics
  • Clozapine
  • Haloperidol
  • NMDA
  • Neuroleptics
  • Prepulse inhibition
  • Ventral hippocampus

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