Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics

Weining Zhang; Bruno Pouzet; Ana L. Jongen-Rêlo; Ina Weiner; Joram Feldon

doi:10.1097/00001756-199908200-00018

Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics

Weining Zhang, Bruno Pouzet, Ana L. Jongen-Rêlo, Ina Weiner, Joram Feldon^*

^*Corresponding author for this work

School of Psychological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The present study tested the effects of the typical neuroleptic haloperidol and an atypical neuroleptic clozapine on ventral hippocampus stimulation-induced disruption of prepulse inhibition (PPI). Bilateral infusions of 0.7 μg NMDA into the ventral hippocampus disrupted PPI. The impairment of PPI following the infusion was completely normalized 24h after the infusion. This disruption of PPI was antagonized by clozapine (5.0 mg/kg), but not by haloperidol (0.2 mg/kg). Since disruption of PPI is considered to constitute an animal model of schizophrenia that is related to the deficit of sensorimotor gating observed in schizophrenic patients, these results suggest that PPI disruption induced by intra-ventral hippocampal infusions of NMDA may serve as an animal model for the selective detection of atypical antipsychotics.

Original language	English
Pages (from-to)	2533-2538
Number of pages	6
Journal	NeuroReport
Volume	10
Issue number	12
DOIs	https://doi.org/10.1097/00001756-199908200-00018
State	Published - 20 Aug 1999

Keywords

Animal model
Antipsychotics
Clozapine
Haloperidol
NMDA
Neuroleptics
Prepulse inhibition
Ventral hippocampus

Access to Document

10.1097/00001756-199908200-00018

Fingerprint

Dive into the research topics of 'Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics'. Together they form a unique fingerprint.

Cite this

Zhang, W., Pouzet, B., Jongen-Rêlo, A. L., Weiner, I., & Feldon, J. (1999). Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics. NeuroReport, 10(12), 2533-2538. https://doi.org/10.1097/00001756-199908200-00018

@article{350e2e41ae874c2f9eb8b1d2604374cf,

title = "Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics",

abstract = "The present study tested the effects of the typical neuroleptic haloperidol and an atypical neuroleptic clozapine on ventral hippocampus stimulation-induced disruption of prepulse inhibition (PPI). Bilateral infusions of 0.7 μg NMDA into the ventral hippocampus disrupted PPI. The impairment of PPI following the infusion was completely normalized 24h after the infusion. This disruption of PPI was antagonized by clozapine (5.0 mg/kg), but not by haloperidol (0.2 mg/kg). Since disruption of PPI is considered to constitute an animal model of schizophrenia that is related to the deficit of sensorimotor gating observed in schizophrenic patients, these results suggest that PPI disruption induced by intra-ventral hippocampal infusions of NMDA may serve as an animal model for the selective detection of atypical antipsychotics.",

keywords = "Animal model, Antipsychotics, Clozapine, Haloperidol, NMDA, Neuroleptics, Prepulse inhibition, Ventral hippocampus",

author = "Weining Zhang and Bruno Pouzet and Jongen-R{\^e}lo, {Ana L.} and Ina Weiner and Joram Feldon",

year = "1999",

month = aug,

day = "20",

doi = "10.1097/00001756-199908200-00018",

language = "אנגלית",

volume = "10",

pages = "2533--2538",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "12",

}

Zhang, W, Pouzet, B, Jongen-Rêlo, AL, Weiner, I & Feldon, J 1999, 'Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics', NeuroReport, vol. 10, no. 12, pp. 2533-2538. https://doi.org/10.1097/00001756-199908200-00018

Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol : A possible model for the screening of atypical antipsychotics. / Zhang, Weining; Pouzet, Bruno; Jongen-Rêlo, Ana L. et al.

In: NeuroReport, Vol. 10, No. 12, 20.08.1999, p. 2533-2538.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol

T2 - A possible model for the screening of atypical antipsychotics

AU - Zhang, Weining

AU - Pouzet, Bruno

AU - Jongen-Rêlo, Ana L.

AU - Weiner, Ina

AU - Feldon, Joram

PY - 1999/8/20

Y1 - 1999/8/20

N2 - The present study tested the effects of the typical neuroleptic haloperidol and an atypical neuroleptic clozapine on ventral hippocampus stimulation-induced disruption of prepulse inhibition (PPI). Bilateral infusions of 0.7 μg NMDA into the ventral hippocampus disrupted PPI. The impairment of PPI following the infusion was completely normalized 24h after the infusion. This disruption of PPI was antagonized by clozapine (5.0 mg/kg), but not by haloperidol (0.2 mg/kg). Since disruption of PPI is considered to constitute an animal model of schizophrenia that is related to the deficit of sensorimotor gating observed in schizophrenic patients, these results suggest that PPI disruption induced by intra-ventral hippocampal infusions of NMDA may serve as an animal model for the selective detection of atypical antipsychotics.

AB - The present study tested the effects of the typical neuroleptic haloperidol and an atypical neuroleptic clozapine on ventral hippocampus stimulation-induced disruption of prepulse inhibition (PPI). Bilateral infusions of 0.7 μg NMDA into the ventral hippocampus disrupted PPI. The impairment of PPI following the infusion was completely normalized 24h after the infusion. This disruption of PPI was antagonized by clozapine (5.0 mg/kg), but not by haloperidol (0.2 mg/kg). Since disruption of PPI is considered to constitute an animal model of schizophrenia that is related to the deficit of sensorimotor gating observed in schizophrenic patients, these results suggest that PPI disruption induced by intra-ventral hippocampal infusions of NMDA may serve as an animal model for the selective detection of atypical antipsychotics.

KW - Animal model

KW - Antipsychotics

KW - Clozapine

KW - Haloperidol

KW - NMDA

KW - Neuroleptics

KW - Prepulse inhibition

KW - Ventral hippocampus

UR - http://www.scopus.com/inward/record.url?scp=0033588463&partnerID=8YFLogxK

U2 - 10.1097/00001756-199908200-00018

DO - 10.1097/00001756-199908200-00018

M3 - מאמר

AN - SCOPUS:0033588463

VL - 10

SP - 2533

EP - 2538

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 12

ER -

Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: A possible model for the screening of atypical antipsychotics

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this