Abstract
The present study tested the effects of the typical neuroleptic haloperidol and an atypical neuroleptic clozapine on ventral hippocampus stimulation-induced disruption of prepulse inhibition (PPI). Bilateral infusions of 0.7 μg NMDA into the ventral hippocampus disrupted PPI. The impairment of PPI following the infusion was completely normalized 24h after the infusion. This disruption of PPI was antagonized by clozapine (5.0 mg/kg), but not by haloperidol (0.2 mg/kg). Since disruption of PPI is considered to constitute an animal model of schizophrenia that is related to the deficit of sensorimotor gating observed in schizophrenic patients, these results suggest that PPI disruption induced by intra-ventral hippocampal infusions of NMDA may serve as an animal model for the selective detection of atypical antipsychotics.
Original language | English |
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Pages (from-to) | 2533-2538 |
Number of pages | 6 |
Journal | NeuroReport |
Volume | 10 |
Issue number | 12 |
DOIs | |
State | Published - 20 Aug 1999 |
Keywords
- Animal model
- Antipsychotics
- Clozapine
- Haloperidol
- NMDA
- Neuroleptics
- Prepulse inhibition
- Ventral hippocampus