Discovering local structure in gene expression data: The order-preserving submatrix problem

Amir Ben-Dor, Benny Chor, Richard Karp, Zohar Yakhini

Research output: Contribution to conferencePaperpeer-review

Abstract

A probabilistic model is defined in which an order-preserving submatrice (OPSM) is hidden within an otherwise random matrix. Guided by this model, an efficient algorithm for finding the hidden OPSM in the random matrix is developed. In data generated according to the model, the algorithm recovers the hidden OPSM with very high success rate. Application of the methods to breast cancer data reveal significant local patterns.

Original languageEnglish
Pages49-57
Number of pages9
StatePublished - 2002
EventRECOMB 2002: Proceedings of the Sixth Annual International Conference on Computational Biology - Washington, DC, United States
Duration: 18 Apr 200221 Apr 2002

Conference

ConferenceRECOMB 2002: Proceedings of the Sixth Annual International Conference on Computational Biology
Country/TerritoryUnited States
CityWashington, DC
Period18/04/0221/04/02

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