TY - JOUR
T1 - Discontinuation of lithium treatment in remitted bipolar patients
T2 - Relationship between clinical outcome and changes in sleep-wake cycles
AU - Klein, Ehud
AU - Mairaz, Rami
AU - Pascal, Martha
AU - Hefez, Albert
AU - Lavie, Peretz
PY - 1991/8
Y1 - 1991/8
N2 - In this preliminary report, we describe four patients in whom long-term lithium therapy was discontinued, combined with actigraphic monitoring to assess changes in motor activity and the sleep-wake cycle. Two patients experienced rapid relapse of manic symptomatology, while two remained stable throughout a 1-year follow-up. Actigraphic monitoring revealed disintegration of the sleep-wake cycle and increased motor activity in the relapsed patients only. It is suggested that actigraphic recordings can be used to monitor lithium discontinuation.
AB - In this preliminary report, we describe four patients in whom long-term lithium therapy was discontinued, combined with actigraphic monitoring to assess changes in motor activity and the sleep-wake cycle. Two patients experienced rapid relapse of manic symptomatology, while two remained stable throughout a 1-year follow-up. Actigraphic monitoring revealed disintegration of the sleep-wake cycle and increased motor activity in the relapsed patients only. It is suggested that actigraphic recordings can be used to monitor lithium discontinuation.
UR - http://www.scopus.com/inward/record.url?scp=0025807654&partnerID=8YFLogxK
U2 - 10.1097/00005053-199108000-00009
DO - 10.1097/00005053-199108000-00009
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C2 - 1856714
AN - SCOPUS:0025807654
SN - 0022-3018
VL - 179
SP - 499
EP - 501
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 8
ER -