TY - JOUR
T1 - Disappearance of diffuse calcinosis following autologous stem cell transplantation in a child with autoimmune disease
AU - Elhasid, R.
AU - Rowe, J. M.
AU - Berkowitz, D.
AU - Ben-Arush, M.
AU - Bar-Shalom, R.
AU - Brik, R.
PY - 2004/6
Y1 - 2004/6
N2 - A 12 year-old girl presented with arthritis, myalgia, anemia and positive ANA. Subsequently, she developed recurrent episodes of pulmonary hemorrhage, thrombo-cytopenia, CNS abnormalities, skin ulcers and diffuse calcinosis. This was followed by secondary antiphospholipid syndrome. Despite vigorous immunosuppression, the patient became bedridden. A peripheral blood stem cell autograft was offered when she developed pulmonary hypertension and digital ischemia at the age of 16 years. The post-transplantation course was uneventful. Liquefaction of calcinosis nodules with improvement of mobility occurred gradually. She is now 24 months post-transplant with no sign of disease activity and total disappearance of calcinosis nodules.
AB - A 12 year-old girl presented with arthritis, myalgia, anemia and positive ANA. Subsequently, she developed recurrent episodes of pulmonary hemorrhage, thrombo-cytopenia, CNS abnormalities, skin ulcers and diffuse calcinosis. This was followed by secondary antiphospholipid syndrome. Despite vigorous immunosuppression, the patient became bedridden. A peripheral blood stem cell autograft was offered when she developed pulmonary hypertension and digital ischemia at the age of 16 years. The post-transplantation course was uneventful. Liquefaction of calcinosis nodules with improvement of mobility occurred gradually. She is now 24 months post-transplant with no sign of disease activity and total disappearance of calcinosis nodules.
KW - Diffuse calcinosis
KW - Peripheral blood stem cell transplantation (PBSCT)
KW - T-cell depletion
UR - http://www.scopus.com/inward/record.url?scp=3242741168&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1704514
DO - 10.1038/sj.bmt.1704514
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C2 - 15077134
AN - SCOPUS:3242741168
SN - 0268-3369
VL - 33
SP - 1257
EP - 1259
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 12
ER -