Direct synthesis of fluorinated heteroarylether bioisosteres

Qianghui Zhou, Alessandro Ruffoni, Ryan Gianatassio, Yuta Fujiwara, Eran Sella, Doron Shabat, Phil S. Baran

Research output: Contribution to journalArticlepeer-review

Abstract

(Bioiso)steering in a new direction: A modular synthesis of reagents (e.g. sodium difluoroethylsulfinate) that can be used for the direct incorporation of difluoroalkyl groups onto heterocycles is reported. The scope and generality of the incorporation of difluoroalkyl groups is exemplified with the difluoroethyl group and a proof of principle is shown for a general synthesis of fluorinated heteroarylether bioisosteres.

Original languageEnglish
Pages (from-to)3949-3952
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number14
DOIs
StatePublished - 2 Apr 2013

Keywords

  • C-H functionalization
  • bioisosteres
  • fluoroalkylation
  • heterocycles
  • synthetic methods

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