Direct evidence for absence of beta-adrenergic receptors in rat cerebral vessels: Histochemical study with a fluorescent beta-blocker

Eldad Melamed, Daphne Atlas, Moshe Lahav

Research output: Contribution to journalArticlepeer-review

Abstract

A fluorescent marker for beta-adrenergic receptor sites, 9-amino-acridin propranolol (9-AAP), was administered intravenously to rats. In contrast to other tissues which are known to con-tain beta-adrenergic receptors, 9-AAP fluorescence was not observed in the walls of the pial as well as parenchymal cerebral vessels. These negative findings strongly suggest that in the rat, beta-adrenergic receptors are not present in the cerebral vasculature. The role of the alpha-adrenergic receptors needs more study.

Original languageEnglish
Pages (from-to)261-263
Number of pages3
JournalStroke
Volume8
Issue number2
DOIs
StatePublished - 1977
Externally publishedYes

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