TY - JOUR
T1 - Direct antitumor effect of high-molecular-weight levan on lewis lung carcinoma cells in mice
AU - Leibovici, Judith
AU - Susskind-Brudner, Genia
N1 - Funding Information:
I Received June 25, 1979; revised February 4, 1980; accepted March 10. 1980. 2 Partly supported by the CiternickFund for Medical Research. 3 Animals were maintained under the guidelines set forth by Tel Aviv University. 4 Department of Pathology. Sackler School of Medicine, Tel Aviv University, Ramat-Aviv, Tel Aviv, Israel. S Department of Pathology, Ch. Sheba Medical Center, Tel Hashomer, Israel. 6 Established Investigator of the Chief Scientist's Bureau, Ministry of Health. Israel. 7 We thank Mrs. Ora Gal-Mor for technical assistance and Mr. N. Rotschild for the animal care.
PY - 1980/8
Y1 - 1980/8
N2 - The polysaccharide levan exerted a direct effect on Lewis lung carcinoma cells in vitro. Tumor cells incubated with levan showed a pronounced decrease in oncogenic properties when inoculated sc in the syngeneic hosts (C57BL mice), although the viability of cells as determined by the trypan blue exclusion test was not diminished. The effect of pretreatment of cells was additively enhanced by in vivo treatment of the inoculated mice with levan. Radiolabel incorporation into DNA, RNA, and protein was not affected in cells incubated with levan, but transport properties were selectively altered: Thymidine, uridine, and leucine transport was enhanced, whereas deoxyglucose transport was unchanged. The results indicated that levan exerted a direct antitumor effect on Lewis lung carcinoma cells in vitro.—JNCI 65: 391-396, 1980.
AB - The polysaccharide levan exerted a direct effect on Lewis lung carcinoma cells in vitro. Tumor cells incubated with levan showed a pronounced decrease in oncogenic properties when inoculated sc in the syngeneic hosts (C57BL mice), although the viability of cells as determined by the trypan blue exclusion test was not diminished. The effect of pretreatment of cells was additively enhanced by in vivo treatment of the inoculated mice with levan. Radiolabel incorporation into DNA, RNA, and protein was not affected in cells incubated with levan, but transport properties were selectively altered: Thymidine, uridine, and leucine transport was enhanced, whereas deoxyglucose transport was unchanged. The results indicated that levan exerted a direct antitumor effect on Lewis lung carcinoma cells in vitro.—JNCI 65: 391-396, 1980.
UR - http://www.scopus.com/inward/record.url?scp=0018832597&partnerID=8YFLogxK
U2 - 10.1093/jnci/65.2.391
DO - 10.1093/jnci/65.2.391
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AN - SCOPUS:0018832597
SN - 0027-8874
VL - 65
SP - 391
EP - 396
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 2
ER -
