Diphenylhydantoin and phenobarbital suppress the dopaminergic neurotoxicity of MPTP in mice

Eldad Melamed*, Giora Martinovits, Eli Pikarsky, Jutta Rosenthal, Anat Uzzan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The combined administration of MPTP with the anticonvulsant drugs diphenylhydantoin or phenobarbital suppressed the MPTP-induced striatal DA depletions in mice. Co-treatment with diazepam, sodium valproate or carbamazepine was ineffective. The mechanism responsible for the protective effect of diphenylhydantoin and phenobarbital against DA neurotoxicity of MPTP is unknown but some previously available findings suggest that they may act, in part, via inhibition of MAO-B and/or DA reuptake in the striatum.

Original languageEnglish
Pages (from-to)255-257
Number of pages3
JournalEuropean Journal of Pharmacology
Volume128
Issue number3
DOIs
StatePublished - 9 Sep 1986
Externally publishedYes

Keywords

  • Carbamazepine
  • Diazepam
  • Diphenylhydantoin
  • Dopaminergic neurotoxicity
  • MPTP
  • Phenobarbital
  • Sodium valproate

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