Diminished decarboxylation of l-dopa in rat striatum after intrastriatal injections of kainic acid

Eldad Melamed*, Franz Hefti, Richard J. Wurtman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Injection of kainic acid into rat striatum reduced striatal DOPA decarboxylase activity by 20% as compared with that in control unlesioned sides. After administration of L-DOPA, concentrations of dopamine (but not DOPA) were lower (by 33%) in lesioned than in control striata indicating decreased in vivo formation of dopamine from exogenous DOPA after kainate lesions. These findings suggest that in the rat, a significant part of striatal DOPA decarboxylase activity i·s localized in neurons originating within the striatum (interneurons and/or efferents) whose perikaria are selectively destroyed by kainic acid.

Original languageEnglish
Pages (from-to)409-411
Number of pages3
JournalNeuropharmacology
Volume19
Issue number4
DOIs
StatePublished - Apr 1980
Externally publishedYes

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