Diminished decarboxylation of l-dopa in rat striatum after intrastriatal injections of kainic acid

Eldad Melamed; Franz Hefti; Richard J. Wurtman

doi:10.1016/0028-3908(80)90194-X

Diminished decarboxylation of l-dopa in rat striatum after intrastriatal injections of kainic acid

Eldad Melamed^*, Franz Hefti, Richard J. Wurtman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Injection of kainic acid into rat striatum reduced striatal DOPA decarboxylase activity by 20% as compared with that in control unlesioned sides. After administration of L-DOPA, concentrations of dopamine (but not DOPA) were lower (by 33%) in lesioned than in control striata indicating decreased in vivo formation of dopamine from exogenous DOPA after kainate lesions. These findings suggest that in the rat, a significant part of striatal DOPA decarboxylase activity i·s localized in neurons originating within the striatum (interneurons and/or efferents) whose perikaria are selectively destroyed by kainic acid.

Original language	English
Pages (from-to)	409-411
Number of pages	3
Journal	Neuropharmacology
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/0028-3908(80)90194-X
State	Published - Apr 1980
Externally published	Yes

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title = "Diminished decarboxylation of l-dopa in rat striatum after intrastriatal injections of kainic acid",

abstract = "Injection of kainic acid into rat striatum reduced striatal DOPA decarboxylase activity by 20% as compared with that in control unlesioned sides. After administration of L-DOPA, concentrations of dopamine (but not DOPA) were lower (by 33%) in lesioned than in control striata indicating decreased in vivo formation of dopamine from exogenous DOPA after kainate lesions. These findings suggest that in the rat, a significant part of striatal DOPA decarboxylase activity i·s localized in neurons originating within the striatum (interneurons and/or efferents) whose perikaria are selectively destroyed by kainic acid.",

author = "Eldad Melamed and Franz Hefti and Wurtman, {Richard J.}",

year = "1980",

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T1 - Diminished decarboxylation of l-dopa in rat striatum after intrastriatal injections of kainic acid

AU - Melamed, Eldad

AU - Hefti, Franz

AU - Wurtman, Richard J.

PY - 1980/4

Y1 - 1980/4

N2 - Injection of kainic acid into rat striatum reduced striatal DOPA decarboxylase activity by 20% as compared with that in control unlesioned sides. After administration of L-DOPA, concentrations of dopamine (but not DOPA) were lower (by 33%) in lesioned than in control striata indicating decreased in vivo formation of dopamine from exogenous DOPA after kainate lesions. These findings suggest that in the rat, a significant part of striatal DOPA decarboxylase activity i·s localized in neurons originating within the striatum (interneurons and/or efferents) whose perikaria are selectively destroyed by kainic acid.

AB - Injection of kainic acid into rat striatum reduced striatal DOPA decarboxylase activity by 20% as compared with that in control unlesioned sides. After administration of L-DOPA, concentrations of dopamine (but not DOPA) were lower (by 33%) in lesioned than in control striata indicating decreased in vivo formation of dopamine from exogenous DOPA after kainate lesions. These findings suggest that in the rat, a significant part of striatal DOPA decarboxylase activity i·s localized in neurons originating within the striatum (interneurons and/or efferents) whose perikaria are selectively destroyed by kainic acid.

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U2 - 10.1016/0028-3908(80)90194-X

DO - 10.1016/0028-3908(80)90194-X

M3 - מאמר

AN - SCOPUS:0018829903

VL - 19

SP - 409

EP - 411

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 4

ER -

Diminished decarboxylation of l-dopa in rat striatum after intrastriatal injections of kainic acid

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