Abstract
Injection of kainic acid into rat striatum reduced striatal DOPA decarboxylase activity by 20% as compared with that in control unlesioned sides. After administration of L-DOPA, concentrations of dopamine (but not DOPA) were lower (by 33%) in lesioned than in control striata indicating decreased in vivo formation of dopamine from exogenous DOPA after kainate lesions. These findings suggest that in the rat, a significant part of striatal DOPA decarboxylase activity i·s localized in neurons originating within the striatum (interneurons and/or efferents) whose perikaria are selectively destroyed by kainic acid.
| Original language | English |
|---|---|
| Pages (from-to) | 409-411 |
| Number of pages | 3 |
| Journal | Neuropharmacology |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1980 |
| Externally published | Yes |