TY - JOUR
T1 - Dimensional complexity of the neuronal activity in a rat model of depression
AU - Dremencov, Eliyahu
AU - Nahshoni, Eitan
AU - Levy, Dino
AU - Mintz, Matti
AU - Overstreet, David H.
AU - Weizman, Abraham
AU - Yadid, Gal
PY - 2004/8/26
Y1 - 2004/8/26
N2 - The Flinders sensitive line of rats is a widely accepted and validated model of depression. These rats demonstrate abnormalities in limbic dopamine neurotransmission, suggesting disturbed neuronal activity in the ventral tegmental area. Interspike interval time-series were recorded from the ventral tegmental area of control Sprague-Dawley and Flinder sensitive line rats. These data were analyzed using standard measures (mean firing rate, bursting activity and spectral analysis) as well as the pointwise correlation dimension, a nonlinear measurement characterizing the complexity degree of dynamic systems. Pointwise correlation dimension, but not standard analysis revealed a significant difference between the animal lines. Our results suggest that nonlinear analyses can detect dysregulation of the mesolimbic dopaminergic system and shed light on the pathophysiology of depression.
AB - The Flinders sensitive line of rats is a widely accepted and validated model of depression. These rats demonstrate abnormalities in limbic dopamine neurotransmission, suggesting disturbed neuronal activity in the ventral tegmental area. Interspike interval time-series were recorded from the ventral tegmental area of control Sprague-Dawley and Flinder sensitive line rats. These data were analyzed using standard measures (mean firing rate, bursting activity and spectral analysis) as well as the pointwise correlation dimension, a nonlinear measurement characterizing the complexity degree of dynamic systems. Pointwise correlation dimension, but not standard analysis revealed a significant difference between the animal lines. Our results suggest that nonlinear analyses can detect dysregulation of the mesolimbic dopaminergic system and shed light on the pathophysiology of depression.
KW - Dopamine
KW - Electrophysiology
KW - Flinders sensitive line of rats
KW - Pointwise correlation dimension
KW - Ventral tegmental area
UR - http://www.scopus.com/inward/record.url?scp=4444284030&partnerID=8YFLogxK
U2 - 10.1097/00001756-200408260-00030
DO - 10.1097/00001756-200408260-00030
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AN - SCOPUS:4444284030
SN - 0959-4965
VL - 15
SP - 1983
EP - 1986
JO - NeuroReport
JF - NeuroReport
IS - 12
ER -