The Digit Symbol Substitution test is simple to administer and sensitive to individual differences related to cognitive performance. The present study evaluated sex-related differences in performance by a Hebrew reading sample. The test was administered to 275 men and 252 women (age range: 20-44 years). Hebrew women significantly scored higher than the men. Means which increased during four consecutive 30-sec. time periods of performance, was significandy greater for the women than the men. This finding indicates women were more effective on this pair-associated learning task than men.