TY - JOUR
T1 - Diffusion NMR spectroscopy in supramolecular and combinatorial chemistry
T2 - An old parameter - New insights
AU - Cohen, Yoram
AU - Avram, Liat
AU - Frish, Limor
N1 - Published also in German:
Diffusions‐NMR‐Spektroskopie in der Supramolekularen und Kombinatorischen Chemie: ein alter Parameter–neue Erkenntnisse
Cohen, Y., Avram, L., Frish, L., 2005,
Angewandte Chemie 117 (4), 524-560.
PY - 2005/1/14
Y1 - 2005/1/14
N2 - Intermolecular interactions in solution play an important role in molecular recognition, which lies at the heart of supramolecular and combinatorial chemistry. Diffusion NMR spectroscopy gives information over such interactions and has become the method of choice for simultaneously measuring diffusion coefficients of multicomponent systems. The diffusion coefficient reflects the effective size and shape of a molecular species. Applications of this technique include the estimation of association constants and mapping the intermolecular interactions in multicomponent systems as well as investigating aggregation, ion pairing, encapsulation, and the size and structure of labile systems. Diffusion NMR spectroscopy can also be used to virtually separate mixtures and screen for specific ligands of different receptors, and may assist in finding lead compounds.
AB - Intermolecular interactions in solution play an important role in molecular recognition, which lies at the heart of supramolecular and combinatorial chemistry. Diffusion NMR spectroscopy gives information over such interactions and has become the method of choice for simultaneously measuring diffusion coefficients of multicomponent systems. The diffusion coefficient reflects the effective size and shape of a molecular species. Applications of this technique include the estimation of association constants and mapping the intermolecular interactions in multicomponent systems as well as investigating aggregation, ion pairing, encapsulation, and the size and structure of labile systems. Diffusion NMR spectroscopy can also be used to virtually separate mixtures and screen for specific ligands of different receptors, and may assist in finding lead compounds.
KW - Combinatorial chemistry
KW - Host-guest chemistry
KW - Molecular recognition
KW - NMR spectroscopy
KW - Supramolecular chemistry
UR - http://www.scopus.com/inward/record.url?scp=13244253788&partnerID=8YFLogxK
U2 - 10.1002/anie.200300637
DO - 10.1002/anie.200300637
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C2 - 15625667
AN - SCOPUS:13244253788
SN - 1433-7851
VL - 44
SP - 520
EP - 554
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 4
ER -