TY - JOUR
T1 - Diffuse, progressive hyperpigmentation
T2 - An unusual skin manifestation of mycosis fungoides
AU - David, Michael
AU - Shanon, Amir
AU - Hazaz, Bilhah
AU - Sandbank, Miriam
PY - 1987
Y1 - 1987
N2 - Pigmentary changes in mycosis fungoides usually occur in association with poikiloderma atrophicans vasculare or following therapy and regression of lesions. Several cases of hypopigmented mycosis fungoides have also been reported. We present the case report of a patient who developed pruritic, diffuse macular hyperpigmentation of the skin. Biopsy specimens from hyperpigmented skin revealed histologic and ultrastructural features typical of mycosis fungoides. Giant melanin granules were found in the tumor cells, as well as in keratinocytes and Langerhans cells. As far as we know, this is the first report of cutaneous hyperpigmentation as a single presenting sign of mycosis fungoides.
AB - Pigmentary changes in mycosis fungoides usually occur in association with poikiloderma atrophicans vasculare or following therapy and regression of lesions. Several cases of hypopigmented mycosis fungoides have also been reported. We present the case report of a patient who developed pruritic, diffuse macular hyperpigmentation of the skin. Biopsy specimens from hyperpigmented skin revealed histologic and ultrastructural features typical of mycosis fungoides. Giant melanin granules were found in the tumor cells, as well as in keratinocytes and Langerhans cells. As far as we know, this is the first report of cutaneous hyperpigmentation as a single presenting sign of mycosis fungoides.
UR - http://www.scopus.com/inward/record.url?scp=0023085045&partnerID=8YFLogxK
U2 - 10.1016/S0190-9622(87)80076-2
DO - 10.1016/S0190-9622(87)80076-2
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0023085045
SN - 0190-9622
VL - 16
SP - 257
EP - 260
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 1
ER -