Diffuse large-cell lymphoma in the elderly: Does a clinically indolent subset exist?

M. Lishner*, D. Amato, B. J. Fernandes, R. Burkes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Among 63 patients with intermediate or high grade non Hodgkin's lymphoma (NHL) seen at our institution in a five-year period, 19 were aged 70 years or older. For various reasons, four of these patients were either not treated or received only minimal treatment. Three of the patients remain well without evidence of disease for 1 to 3 years, and the fourth has relapsed in an indolent fashion after 3 years. These observations suggest that existence of a subset of patients with histologically aggressive non-Hodgkin's lymphoma whose disease behaves mildly. Because of the high incidence of treatment-related morbidity and mortality in elderly lymphoma patients treated with combination chemotherapy, it is important to try to identify prospectively this subset of patients clinically and to avoid overtreatment in this category of cases.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalLeukemia and Lymphoma
Issue number3
StatePublished - 1991
Externally publishedYes


  • High grade Elderly patients
  • Non-Hodgkin's lymphoma


Dive into the research topics of 'Diffuse large-cell lymphoma in the elderly: Does a clinically indolent subset exist?'. Together they form a unique fingerprint.

Cite this