Differentition of steroid-induced leucocytosis from the sepsis-induced increment in peripheral blood white blood cells by means of a functional marker on the surface of peripheral blood polymorphonuclear leucocytes

Eyal Leibovitz, Nadir Arber, Asher Winder, Shlomo Berliner

Research output: Contribution to journalArticlepeer-review

Abstract

A study of 13 patients with septic conditions, six with chronic obstructive pulmonary disease and 17 controls showed that it is possible to differentiate between corticosteroid-induced and the leucocytosis induced by septic conditions, by using a functional marker on the surface of peripheral blood polymorphonuclear leucocytes (PMNs). This marker was a blocking sensitive anti-human fibrinogen monoclonal antibody that probably recognises human Fc receptor on the surface of the PMNs by its Fc portion. This is the most reasonable explanation for the finding that we could abolish most of the binding by pre-incubation of the cells with purified human gamma globulin.

Original languageEnglish
Pages (from-to)369-370
Number of pages2
JournalMedical Science Research
Volume24
Issue number6
StatePublished - 1996

Keywords

  • Peripheral blood polymorphonuclear leucocytes
  • Sepsis

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