A study of 13 patients with septic conditions, six with chronic obstructive pulmonary disease and 17 controls showed that it is possible to differentiate between corticosteroid-induced and the leucocytosis induced by septic conditions, by using a functional marker on the surface of peripheral blood polymorphonuclear leucocytes (PMNs). This marker was a blocking sensitive anti-human fibrinogen monoclonal antibody that probably recognises human Fc receptor on the surface of the PMNs by its Fc portion. This is the most reasonable explanation for the finding that we could abolish most of the binding by pre-incubation of the cells with purified human gamma globulin.
|Number of pages||2|
|Journal||Medical Science Research|
|State||Published - 1996|
- Peripheral blood polymorphonuclear leucocytes