@article{00ee67d0e67941cea9775daf47398eaf,
title = "Differentiation and characterization of Tr1 cells",
abstract = "Regulatory T cell-mediated suppression serves as a pivotal mechanism of negative regulation of immune-mediated inflammation. Type 1 regulatory T cells (Tr1 cells) are an important subset of CD4+ T cells that prevent excessive inflammatory responses and maintain immune tolerance. The antiinflammatory role of Tr1 cells is mediated in part by their production of interleukin 10 (IL-10), which dampens the function of both antigen-presenting cells and antigen-specific effector T cells. Additionally, Tr1 cells can kill effector and myeloid cells through the perforin-granzyme B pathway. Adoptive transfer of in vitro differentiated Tr1 cells can be used to suppress autoimmune tissue inflammation in vivo. This unit describes the in vitro stimulation of na{\"i}ve murine CD4+ T cells using IL-27 to generate IL-10-producing Tr1 cells.",
keywords = "CD4, IL-10, IL-27, T cell differentiation, Tr1",
author = "Norio Chihara and Asaf Madi and Katarzyna Karwacz and Amit Awasthi and Kuchroo, {Vijay K.}",
note = "Publisher Copyright: {\textcopyright} 2016 by John Wiley & Sons, Inc.",
year = "2016",
doi = "10.1002/0471142735.im0327s113",
language = "אנגלית",
volume = "2016",
pages = "3.27.1--3.27.10",
journal = "Current Protocols in Immunology",
issn = "1934-3671",
publisher = "John Wiley & Sons Inc.",
}