TY - JOUR
T1 - Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia
T2 - an update on imaging modalities
AU - Orad, Rotem Iris
AU - Shiner, Tamara
N1 - Publisher Copyright:
© 2021, Springer-Verlag GmbH, DE part of Springer Nature.
PY - 2022/2
Y1 - 2022/2
N2 - Dementia with Lewy bodies is the second most common cause of neurodegenerative dementia after Alzheimer's disease. Dementia with Lewy bodies can provide a diagnostic challenge due to the frequent overlap of clinical signs with other neurodegenerative conditions, namely Parkinson's disease dementia, and Alzheimer's disease. Part of this clinical overlap is due to the neuropathological overlap. Dementia with Lewy bodies is characterized by the accumulation of aggregated α-synuclein protein in Lewy bodies, similar to Parkinson's disease and Parkinson's disease dementia. However, it is also frequently accompanied by aggregation of amyloid-beta and tau, the pathological hallmarks of Alzheimer's disease. Neuroimaging is central to the diagnostic process. This review is an overview of both established and evolving imaging methods that can improve diagnostic accuracy and improve management of this disorder.
AB - Dementia with Lewy bodies is the second most common cause of neurodegenerative dementia after Alzheimer's disease. Dementia with Lewy bodies can provide a diagnostic challenge due to the frequent overlap of clinical signs with other neurodegenerative conditions, namely Parkinson's disease dementia, and Alzheimer's disease. Part of this clinical overlap is due to the neuropathological overlap. Dementia with Lewy bodies is characterized by the accumulation of aggregated α-synuclein protein in Lewy bodies, similar to Parkinson's disease and Parkinson's disease dementia. However, it is also frequently accompanied by aggregation of amyloid-beta and tau, the pathological hallmarks of Alzheimer's disease. Neuroimaging is central to the diagnostic process. This review is an overview of both established and evolving imaging methods that can improve diagnostic accuracy and improve management of this disorder.
KW - Alzheimer's disease
KW - Dementia with lewy bodies
KW - Imaging
KW - Magnetic resonance imaging
KW - Parkinson's disease dementia
UR - http://www.scopus.com/inward/record.url?scp=85099833764&partnerID=8YFLogxK
U2 - 10.1007/s00415-021-10402-2
DO - 10.1007/s00415-021-10402-2
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C2 - 33511432
AN - SCOPUS:85099833764
SN - 0340-5354
VL - 269
SP - 639
EP - 653
JO - Journal of Neurology
JF - Journal of Neurology
IS - 2
ER -