TY - JOUR
T1 - Differentiating between Cancer and Inflammation
T2 - A Metabolic-Based Method for Functional Computed Tomography Imaging
AU - Motiei, Menachem
AU - Dreifuss, Tamar
AU - Betzer, Oshra
AU - Panet, Hana
AU - Popovtzer, Aron
AU - Santana, Jordan
AU - Abourbeh, Galith
AU - Mishani, Eyal
AU - Popovtzer, Rachela
N1 - Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/3/22
Y1 - 2016/3/22
N2 - One of the main limitations of the highly used cancer imaging technique, PET-CT, is its inability to distinguish between cancerous lesions and post treatment inflammatory conditions. The reason for this lack of specificity is that [18F]FDG-PET is based on increased glucose metabolic activity, which characterizes both cancerous tissues and inflammatory cells. To overcome this limitation, we developed a nanoparticle-based approach, utilizing glucose-functionalized gold nanoparticles (GF-GNPs) as a metabolically targeted CT contrast agent. Our approach demonstrates specific tumor targeting and has successfully distinguished between cancer and inflammatory processes in a combined tumor-inflammation mouse model, due to dissimilarities in angiogenesis occurring under different pathologic conditions. This study provides a set of capabilities in cancer detection, staging and follow-up, and can be applicable to a wide range of cancers that exhibit high metabolic activity.
AB - One of the main limitations of the highly used cancer imaging technique, PET-CT, is its inability to distinguish between cancerous lesions and post treatment inflammatory conditions. The reason for this lack of specificity is that [18F]FDG-PET is based on increased glucose metabolic activity, which characterizes both cancerous tissues and inflammatory cells. To overcome this limitation, we developed a nanoparticle-based approach, utilizing glucose-functionalized gold nanoparticles (GF-GNPs) as a metabolically targeted CT contrast agent. Our approach demonstrates specific tumor targeting and has successfully distinguished between cancer and inflammatory processes in a combined tumor-inflammation mouse model, due to dissimilarities in angiogenesis occurring under different pathologic conditions. This study provides a set of capabilities in cancer detection, staging and follow-up, and can be applicable to a wide range of cancers that exhibit high metabolic activity.
KW - CT
KW - FDG-PET
KW - cancer
KW - gold nanoparticles
KW - metabolic-based imaging
UR - http://www.scopus.com/inward/record.url?scp=84961941254&partnerID=8YFLogxK
U2 - 10.1021/acsnano.5b07576
DO - 10.1021/acsnano.5b07576
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C2 - 26886076
AN - SCOPUS:84961941254
SN - 1936-0851
VL - 10
SP - 3469
EP - 3477
JO - ACS Nano
JF - ACS Nano
IS - 3
ER -
