TY - JOUR
T1 - Differentiated thyroid cancer in childhood
T2 - Pathology, diagnosis, therapy
AU - Reiners, Christoph
AU - Demidchik, Yuri E.
AU - Kohrle, J.
AU - Reiners, C.
AU - Laron, Z.
AU - Bundok, R.
AU - Bober, E.
AU - Sack, J.
AU - Saka, N.
AU - Graziano, C.
AU - Kraiem, Z.
PY - 2003/12
Y1 - 2003/12
N2 - The incidence of thyroid cancer in childhood amounts to approximately 0,5/100.000/year. However, after exposure to ionizing irradiation, the incidence may increase more than 20 fold. In children, lymph node metastases of differentiated thyroid cancer are frequent (more than 50%); distant metastases mainly to the lung are seen in 20-30%. The method of choice for the primary diagnosis of thyroid cancer today is ultrasonography with 7,5 - 10 MHz probes, accompanied by fine-needle aspiration biopsy. Differentiated thyroid cancer has to be treated with a multidisciplinary approach comprising total thyroidectomy and lymph node dissection, post-operative radioiodine treatment and TSH-suppression by levothyroxine. The long-term results of this treatment approach are generally good with 10-year survival rates of 95% and higher. The treatment of children with disseminated pulmonary metastases however, may be complicated due to the increased risk of the induction of pulmonary fibrosis by radioiodine.
AB - The incidence of thyroid cancer in childhood amounts to approximately 0,5/100.000/year. However, after exposure to ionizing irradiation, the incidence may increase more than 20 fold. In children, lymph node metastases of differentiated thyroid cancer are frequent (more than 50%); distant metastases mainly to the lung are seen in 20-30%. The method of choice for the primary diagnosis of thyroid cancer today is ultrasonography with 7,5 - 10 MHz probes, accompanied by fine-needle aspiration biopsy. Differentiated thyroid cancer has to be treated with a multidisciplinary approach comprising total thyroidectomy and lymph node dissection, post-operative radioiodine treatment and TSH-suppression by levothyroxine. The long-term results of this treatment approach are generally good with 10-year survival rates of 95% and higher. The treatment of children with disseminated pulmonary metastases however, may be complicated due to the increased risk of the induction of pulmonary fibrosis by radioiodine.
KW - Childhood and adolescence
KW - Differentiated thyroid cancer
KW - Fine-needle aspiration biopsy
KW - Radiation induction
KW - Radioiodine therapy
KW - Surgery
KW - Ultrasound diagnosis
UR - http://www.scopus.com/inward/record.url?scp=13444312031&partnerID=8YFLogxK
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AN - SCOPUS:13444312031
SN - 1565-4753
VL - 1
SP - 230
EP - 236
JO - Pediatric Endocrinology Reviews
JF - Pediatric Endocrinology Reviews
IS - SUPLL. 2
ER -
