Differential Solubilities in Subregions of the Membrane: A Nonsteric Mechanism of Drug Specificity

Emmanuel M. Landau; Jacob Richter; Sasson Cohen

doi:10.1021/jm00189a023

Differential Solubilities in Subregions of the Membrane: A Nonsteric Mechanism of Drug Specificity

Emmanuel M. Landau, Jacob Richter, Sasson Cohen

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the effect of four volatile anesthetics and convulsants on the GABA-and glutamate-induced conductance change in crab muscle. The intensity of drug action correlated with the solubility parameter (δ) values of the four drugs. Thus, the higher that value was for a given drug, the stronger was its effect on the glutamate response but the weaker was it on the response to γ-aminobutyric acid (GABA). We suggest that different gating molecules are housed in specific subregions of the membrane, each characterized by a particular value of the solubility parameter. The differential distribution of drugs in these subregions may be a nonsteric mechanism for drug specificity.

Original language	English
Pages (from-to)	325-327
Number of pages	3
Journal	Journal of Medicinal Chemistry
Volume	22
Issue number	3
DOIs	https://doi.org/10.1021/jm00189a023
State	Published - 1 Feb 1979

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Differential Solubilities in Subregions of the Membrane: A Nonsteric Mechanism of Drug Specificity

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