Abstract
Abstract: Electroconvulsive shock (ECS) administrations repeated for 10 consecutive days cause an elevation in the opioid content of the rat brain. Two different endogenous opioids, enkephalin and humoral‐endorphin, undergo independent changes that differ in both their time course and intracerebral localization. These metabolic changes parallel long‐term behavioral modifications such as the development and dissipation of tolerance to the analgesic effect of ECS. The activation of two different, independent, endogenous opioid systems by ECS is in agreement with previous behavioral and pharmacological studies.
| Original language | English |
|---|---|
| Pages (from-to) | 1478-1480 |
| Number of pages | 3 |
| Journal | Journal of Neurochemistry |
| Volume | 39 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1982 |
Keywords
- Analgesia
- Electroconvulsive shock
- Endorphin
- Enkephalin
- Opioids
- Tolerance