Differential Effects of Long‐Term Electroconvulsive Shock on Brain Levels of Enkephalin and Humoral‐Endorphin

Y. Same, B. A. Weissman, G. Urca

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: Electroconvulsive shock (ECS) administrations repeated for 10 consecutive days cause an elevation in the opioid content of the rat brain. Two different endogenous opioids, enkephalin and humoral‐endorphin, undergo independent changes that differ in both their time course and intracerebral localization. These metabolic changes parallel long‐term behavioral modifications such as the development and dissipation of tolerance to the analgesic effect of ECS. The activation of two different, independent, endogenous opioid systems by ECS is in agreement with previous behavioral and pharmacological studies.

Original languageEnglish
Pages (from-to)1478-1480
Number of pages3
JournalJournal of Neurochemistry
Volume39
Issue number5
DOIs
StatePublished - Nov 1982

Keywords

  • Analgesia
  • Electroconvulsive shock
  • Endorphin
  • Enkephalin
  • Opioids
  • Tolerance

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