Differential effects of D1 and D2 dopamine agonists on stereotyped locomotion in rats

David Eilam, Kathleen V.A. Clements, Henry Szechtman

Research output: Contribution to journalArticlepeer-review

Abstract

The study examines the effect of selective D1 dopamine stimulation with SKF38393 (1.25-10 mg/kg), on stereotyped locomotion induced by the D2 agonist, quinpirole (0.5 mg/kg). Quinpirole induces repeated travel along a few routes in a limited portion of the environment. Co-administration of low doses of SKF38393 (1.25-2.5 mg/kg) produces the following results: the rate of route perseveration is not affected; the area explored expands to encompass the entire periphery of the open field; and, the spatial distribution of locomotion is transformed from routes that cross the center under quinpirole to travel only along the edge. Under higher doses of SKF38393, locomotion ceases. These findings suggest that D1 and D2 stimulation may control the spatial organization of locomotion in oppositional rather than synergistic manner.

Original languageEnglish
Pages (from-to)117-124
Number of pages8
JournalBehavioural Brain Research
Volume45
Issue number2
DOIs
StatePublished - 26 Nov 1991
Externally publishedYes

Keywords

  • D1/D2 interaction
  • Dopamine
  • Open field behavior
  • Quinpirole
  • Rat
  • Route
  • SKF38393

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