@article{2247d537fce1496aa489a3657381034e,
title = "Differential effects of D1 and D2 dopamine agonists on stereotyped locomotion in rats",
abstract = "The study examines the effect of selective D1 dopamine stimulation with SKF38393 (1.25-10 mg/kg), on stereotyped locomotion induced by the D2 agonist, quinpirole (0.5 mg/kg). Quinpirole induces repeated travel along a few routes in a limited portion of the environment. Co-administration of low doses of SKF38393 (1.25-2.5 mg/kg) produces the following results: the rate of route perseveration is not affected; the area explored expands to encompass the entire periphery of the open field; and, the spatial distribution of locomotion is transformed from routes that cross the center under quinpirole to travel only along the edge. Under higher doses of SKF38393, locomotion ceases. These findings suggest that D1 and D2 stimulation may control the spatial organization of locomotion in oppositional rather than synergistic manner.",
keywords = "D1/D2 interaction, Dopamine, Open field behavior, Quinpirole, Rat, Route, SKF38393",
author = "David Eilam and Clements, {Kathleen V.A.} and Henry Szechtman",
note = "Funding Information: This study was supported by funds from the Medical Research Council of Canada (MA8905) and the Scottish Rite Schizophrenia Research Program, N.M.J., U.S.A.H.S. is a Research Associate of the Ontario Mental Health Foundation. D.E. is Allon Fellow of the High Education Council of Israel. Lilly Research Laboratories provided a generous gift ofquin-pirole hydrochloride.",
year = "1991",
month = nov,
day = "26",
doi = "10.1016/S0166-4328(05)80077-4",
language = "אנגלית",
volume = "45",
pages = "117--124",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier B.V.",
number = "2",
}