Differential effect of polycations on uptake and desulphation of heparin.

I. Fabian*, I. Bleiberg, M. Aronson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Previous work has established that macrophages in culture release sulphate from heparin. We now report that increased uptake and desulphation of heparin occurred in the presence of polycations (poly-L-ornithine and poly-DL-lysine) and that the increase in heparin uptake was by about 30-fold. The desulphation was less related to uptake than to the nature of the bound polycation. Serum was found to have an inhibitory effect on heparin uptake while polycations inhibited heparin desulphation by macrophage extracts.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Issue numberA
StatePublished - 1979


Dive into the research topics of 'Differential effect of polycations on uptake and desulphation of heparin.'. Together they form a unique fingerprint.

Cite this