@article{c5d9cebde9594ef8bf99244f98df3c33,
title = "Differential effect of pH on sodium binding by the various GABA transporters expressed in Xenopus oocytes",
abstract = "Mouse GABA transporters belong to the family of Na+- and Cl--dependent neurotransmitter transporters. The four GABA transporters exhibit unique presteady-state currents when expressed in Xenopus oocytes. The properties of the presteady-state currents correspond to their different affinities to Na+. In the presence of 20 μM GABA and at pH 7.5, the half-maximal uptake activity was 47, 120, 25 and 35 mM Na+ for GAT1, GAT2, GAT3 and GAT4, respectively. The appearance of presteady-state currents at positive or negative imposed potentials was in correlation with the affinity to Na+. Changing the external pH differentially affected the GABA uptake and the presteady-state activities of the various GABA transporters. It is suggested that protons compete with Na+ on its binding site; however, the proton binding is not productive and is unable to drive GABA uptake.",
keywords = "Neurotransmitter, Proton, Sodium, Transport, Transporter, γ-Aminobutyric acid",
author = "Grossman, {Tamar R.} and Nathan Nelson",
note = "Funding Information: This work was supported by a grant from the United States–Israel Binational Scientific Foundation.",
year = "2002",
month = sep,
day = "11",
doi = "10.1016/S0014-5793(02)03194-0",
language = "אנגלית",
volume = "527",
pages = "125--132",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "1-3",
}