Differential effect of lithium treatment on fenfluramine-induced decreases in food intake and locomotor activity in rats

C. S. Aulakh, J. Zohar, J. L. Hill, D. L. Murphy

Research output: Contribution to journalArticlepeer-review

Abstract

Administration of fenfluramine to rats decreased 1-h food intake and locomotor activity. Short-term (2-6 days) but not long-term (21-25 days) lithium treatment potentiated fenfluramine-induced suppression of food intake. However, neither short-term nor long-term lithium treatment had any significant effect on fenfluramine-induced suppression of locomotor activity. These findings demonstrate a differential effect of lithium treatment on fenfluramine-induced suppression of food intake and locomotor activity. Furthermore, these findings are consistent with results from several other animal and clinical studies demonstrating a differential effect of lithium treatment on two different serotonin-mediated functions.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalJournal of Psychopharmacology
Volume5
Issue number2
DOIs
StatePublished - Mar 1991
Externally publishedYes

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