Differential effect of acute and chronic haloperidol administration on dopamine turnover in rat nigrostriatal and retinal dopaminergic neurons

Eldad Melamed, Rimona Durst, Yosef Frucht, Mordechai Globus

Research output: Contribution to journalArticlepeer-review

Abstract

Haloperidol-induced increases in DOPAC and HVA declined in the striatum but remained unchanged in the retina after chronic pretreatment with haloperidol (1-4 weeks). DA concentrations were unaffected in the striatum but decreased in the retina after acute or chronic haloperidol administration. Light stimulation increased both retinal DA and DOPAC. The findings indicate that acute and chronic haloperidol affect nigrostriatal and retinal DA neurons differentially. In addition, DA neurons in retina respond differently to activations by haloperidol and light.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalEuropean Journal of Pharmacology
Volume89
Issue number3-4
DOIs
StatePublished - 6 May 1983
Externally publishedYes

Keywords

  • Dopamine turnover
  • Haloperidol
  • Light stimulation
  • Retina
  • Striatum

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