Different pathways of endothelin/sarafotoxin-stimulated phosphoinositide hydrolysis in myocytes

Ronit Galron; Yoel Kloog; Avner Bdolah; Mordechai Sokolovsky

doi:10.1016/0922-4106(90)90251-R

Different pathways of endothelin/sarafotoxin-stimulated phosphoinositide hydrolysis in myocytes

Ronit Galron, Yoel Kloog, Avner Bdolah, Mordechai Sokolovsky^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Aging of rat heart myocytes in culture is accompanied by ∼ 50% reduction in endothelin (ET)/sarafotoxin (SRTX) receptor-binding capacity as well as in the induction of phosphoinositide (PI) hydrolysis. Treatment of aged cultures under conditions yielding myocytes with a lipid composition similar to that in young cultures restored all the ET/SRTX receptors; at the same time it re-established only the endothelin-induced but not the sarafotoxin-induced PI-hydrolysis response. Thus more than one mechanism may stimulate PI metabolism.

Original language	English
Pages (from-to)	85-88
Number of pages	4
Journal	European Journal of Pharmacology: Molecular Pharmacology
Volume	188
Issue number	1
DOIs	https://doi.org/10.1016/0922-4106(90)90251-R
State	Published - 23 Jan 1990

Keywords

Aging (Receptor)
Endothelins
Heart (rat)
Phosphoinositide hydrolysis
Sarafotoxins

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10.1016/0922-4106(90)90251-R

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abstract = "Aging of rat heart myocytes in culture is accompanied by ∼ 50% reduction in endothelin (ET)/sarafotoxin (SRTX) receptor-binding capacity as well as in the induction of phosphoinositide (PI) hydrolysis. Treatment of aged cultures under conditions yielding myocytes with a lipid composition similar to that in young cultures restored all the ET/SRTX receptors; at the same time it re-established only the endothelin-induced but not the sarafotoxin-induced PI-hydrolysis response. Thus more than one mechanism may stimulate PI metabolism.",

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AB - Aging of rat heart myocytes in culture is accompanied by ∼ 50% reduction in endothelin (ET)/sarafotoxin (SRTX) receptor-binding capacity as well as in the induction of phosphoinositide (PI) hydrolysis. Treatment of aged cultures under conditions yielding myocytes with a lipid composition similar to that in young cultures restored all the ET/SRTX receptors; at the same time it re-established only the endothelin-induced but not the sarafotoxin-induced PI-hydrolysis response. Thus more than one mechanism may stimulate PI metabolism.

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Different pathways of endothelin/sarafotoxin-stimulated phosphoinositide hydrolysis in myocytes

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