Different pathways of endothelin/sarafotoxin-stimulated phosphoinositide hydrolysis in myocytes

Ronit Galron, Yoel Kloog, Avner Bdolah, Mordechai Sokolovsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aging of rat heart myocytes in culture is accompanied by ∼ 50% reduction in endothelin (ET)/sarafotoxin (SRTX) receptor-binding capacity as well as in the induction of phosphoinositide (PI) hydrolysis. Treatment of aged cultures under conditions yielding myocytes with a lipid composition similar to that in young cultures restored all the ET/SRTX receptors; at the same time it re-established only the endothelin-induced but not the sarafotoxin-induced PI-hydrolysis response. Thus more than one mechanism may stimulate PI metabolism.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume188
Issue number1
DOIs
StatePublished - 23 Jan 1990

Keywords

  • Aging (Receptor)
  • Endothelins
  • Heart (rat)
  • Phosphoinositide hydrolysis
  • Sarafotoxins

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