Different coexisting endometrial histological features in asymptomatic postmenopausal breast cancer patients treated with tamoxifen

Ilan Cohen, Marco M. Altaras, Jeremiah Shapira, Ron Tepper, Mario Cordoba, Arie Figere, Yaron Zalel, Yigael Dror, Yoram Beyth

Research output: Contribution to journalArticlepeer-review

Abstract

In an attempt to assess the hypothesis that different endometrial sites may respond differently to tamoxifen exposure in postmenopausal women, hysteroscopic selected endometrial histology was investigated in 175 postmenopausal breast cancer patients who received continuous treatment with tamoxifen, and in 27 similar patients not treated with tamoxifen who served as controls. In the tamoxifen-treated patients 14 (8.0%) developed endometrial polyps. Of 14 patients, 8 (57.2%) each displayed atrophic endometrium in the same histologic specimen, 5 (35.7%) each had coexisting simple hyperplasia, and 1 (7.1%) other had complex hyperplasia. Another 21 (12.0%) developed simple or complex hyperplasia. The endometrial hyperplasia coexisted with atrophic endometrium in all these patients. All these lesions were selectively identified by hysteroscopic examination prior to the endometrial biopsy. In the control group 3 (11.0%) had simple hyperplasia and 2 (7.4%) had endometrial polyps. The above results support the hypothesis that the endometrium of postmenopausal breast cancer patients on tamoxifen treatment may possess different responses to tamoxifen exposure.

Original languageEnglish
Pages (from-to)60-63
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume43
Issue number1
DOIs
StatePublished - 1 Jan 1997

Keywords

  • Endometrial histology
  • Postmenopausal tamoxifen

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