Different behavioral deficits are induced by anoxia/hypoxia in neonatal and senescent rats: blockade by MK-801

Zipora Speiser*, Joseph Uziel, Ruth Defrin-Assa, Simon Gitter, Gideon Urca

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Rats exposed on their first postnatal day to 100% nitrogen for 25 min developed hyperactivity and lower performance in passive avoidance task during development. Administration of MK-801 (0.5 mg/kg i.p.) 1 h before anoxia or (0.25 and 0.5 mg/kg) 1 h after completely reversed this behavioral impairement. Senescent rats (24-26 months) exposed to hypoxia (92% N2+8% O2) for 5 h failed in their performance in C.A.R., 30 days later. Pretreatment with MK-801 (1 mg/kg i.p.) completely reversed this impairment. These data suggest that activation of endogenous NMDA receptors produces different behavioral consequences in neonatal and senescent rats and that MK-801 administration close to exposure of animals to anoxia or hypoxia can prevent such damage, thus preventing behavioral impairments in postnatal, as well as in senescent rats.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalBehavioural Brain Research
Volume42
Issue number2
DOIs
StatePublished - 28 Feb 1991

Funding

FundersFunder number
Herzeg-Schwartz-Krauthamer Foundation
Rekanati Foundation for Geriatric Research

    Keywords

    • Active avoidance test
    • Anoxia
    • Hyperactivity
    • Hypoxia
    • MK-801
    • Passive avoidance test
    • Postnatal rat
    • Senescent rat

    Fingerprint

    Dive into the research topics of 'Different behavioral deficits are induced by anoxia/hypoxia in neonatal and senescent rats: blockade by MK-801'. Together they form a unique fingerprint.

    Cite this