Differences in the expression of SPI-1 genes pathogenicity and epidemiology between the emerging Salmonella enterica serovar Infantis and the model Salmonella enterica serovar Typhimurium

Gili Aviv, Antje Cornelius, Maya Davidovich, Helit Cohen, Abdulhadi Suwandi, Alibek Galeev, Natalie Steck, Shalhevet Azriel, Assaf Rokney, Lea Valinsky, Galia Rahav, Guntram A. Grassl, Ohad Gal-Mor

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Salmonella enterica serovar Infantis (S. Infantis) is one of the ubiquitous serovars of the bacterial pathogen S. enterica and recently has been emerging in many countries worldwide. Nonetheless, not much is known about its epidemiology, host adaptation, and virulence. Methods: Epidemiological and molecular approaches were used together with tissue-culture and mouse models to conduct phenotypic comparison with the model S. enterica serovar Typhimurium. Results: We show that S. Infantis is more frequently associated with infections in infants <2 years old and prone to cause significantly less invasive infections than serovar Typhimurium. Moreover, although S. Infantis adheres better to host cells and highly colonizes mouse intestines soon after infection, it is significantly less invasive and induces much lower inflammation and disease in vivo than S. Typhimurium. These differences were associated with lower expression of Salmonella pathogenicity island (SPI) 1 genes in S. Infantis than in S. Typhimurium. Conclusions: Our results demonstrate previously unknown differences in the epidemiology, virulence pathway expression, and pathogenicity between two highly abundant Salmonella serovars and suggest that native variation in the expression of the SPI-1 regulon is likely to contribute to epidemiological and virulence variation between genetically similar nontyphoidal Salmonella serovars.

Original languageEnglish
Pages (from-to)1071-1081
Number of pages11
JournalJournal of Infectious Diseases
Volume220
Issue number6
DOIs
StatePublished - 9 Aug 2019

Keywords

  • Salmonella enterica
  • Salmonella-pathogenicity islands
  • gastroenteritis
  • host-pathogen interactions
  • invasion
  • pathogenicity
  • salmonellosis
  • virulence

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