Differences in Telomere Length between Adolescent Females with Anorexia Nervosa Restricting Type and Anorexia Nervosa Binge-Purge Type

Orit Uziel, Hadar Dickstein, Einat Beery, Yael Lewis, Ron Loewenthal, Eran Uziel, Zipi Shochat, Abraham Weizman, Daniel Stein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Physiological and psychological distress may accelerate cellular aging, manifested by shortening of telomere length (TL). The present study focused on TL shortening in anorexia nervosa (AN), an illness combining physiological and psychological distress. For that purpose, we measured TL in 44 female adolescents with AN at admission to inpatient treatment, in a subset of 18 patients also at discharge, and in 22 controls. No differences in TL were found between patients with AN and controls. At admission, patients with AN-binge/purge type (AN-B/P; n = 18) showed shorter TL compared with patients with AN-restricting type (AN-R; n = 26). No change in TL was found from admission to discharge, despite an improvement in body mass index standard deviation score (BMI-SDS) following inpatient treatment. Older age was the only parameter assessed to be correlated with greater TL shortening. Several methodological changes have to be undertaken to better understand the putative association of shorter TL with B/P behaviors, including increasing the sample size and the assessment of the relevant pathological eating disorder (ED) and non-ED psychological correlates in the two AN subtypes.

Original languageEnglish
Article number2596
JournalNutrients
Volume15
Issue number11
DOIs
StatePublished - Jun 2023

Keywords

  • adolescence
  • anorexia nervosa
  • eating disorders
  • telomere length

Fingerprint

Dive into the research topics of 'Differences in Telomere Length between Adolescent Females with Anorexia Nervosa Restricting Type and Anorexia Nervosa Binge-Purge Type'. Together they form a unique fingerprint.

Cite this