Differences in metabolite levels upon differentiation of intact neuroblastoma × glioma cells observed by proton NMR spectroscopy

Gil Navon, Howard Burrows, Jack S. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Proton NMR spectroscopy was used to study the effect of differentiation with prostaglandin E1 and theophylline on intact hybrid neuroblastoma × glioma cells. The standard proton NMR method showed more resolvable signals than the spin echo NMR spectra. The differentiated cells were found to contain significantly higher levels of glutamine than the undifferentiated precursors. Observations on cell extracts confirmed these results.

Original languageEnglish
Pages (from-to)320-323
Number of pages4
JournalFEBS Letters
Volume162
Issue number2
DOIs
StatePublished - 17 Oct 1983
Externally publishedYes

Keywords

  • Differentiation
  • Glutamine
  • Neuroblastoma × glioma cell
  • Prostaglandin E
  • Proton NMR vs spin-echo
  • Theophylline

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