Difference in 11β-hydroxylation of deoxycortisol and deoxycorticosterone by human adrenals

A. Klein, H. Ch Curtius, M. Zachmann

Research output: Contribution to journalArticlepeer-review

Abstract

Human adrenals obtained up to 12 h after death, were homogenized and used as a 11β-hydroxylase preparation. Two kinds of incubations, each containing 11-deoxycorticosterone (DOC) and 11-deoxycortisol (compound S) as substrates, were performed. One incubation was carried out at various temperatures (25-38°C) and the other using a heat inhibition method. The results indicate a difference in the hydroxylation of 11-deoxycortisol to cortisol (compound F) and 11-deoxycorticosterone to corticosterone (compound B).

Original languageEnglish
Pages (from-to)557-560
Number of pages4
JournalJournal of Steroid Biochemistry
Volume5
Issue number6
DOIs
StatePublished - Oct 1974
Externally publishedYes

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