TY - JOUR
T1 - Difference in 11β-hydroxylation of deoxycortisol and deoxycorticosterone by human adrenals
AU - Klein, A.
AU - Curtius, H. Ch
AU - Zachmann, M.
PY - 1974/10
Y1 - 1974/10
N2 - Human adrenals obtained up to 12 h after death, were homogenized and used as a 11β-hydroxylase preparation. Two kinds of incubations, each containing 11-deoxycorticosterone (DOC) and 11-deoxycortisol (compound S) as substrates, were performed. One incubation was carried out at various temperatures (25-38°C) and the other using a heat inhibition method. The results indicate a difference in the hydroxylation of 11-deoxycortisol to cortisol (compound F) and 11-deoxycorticosterone to corticosterone (compound B).
AB - Human adrenals obtained up to 12 h after death, were homogenized and used as a 11β-hydroxylase preparation. Two kinds of incubations, each containing 11-deoxycorticosterone (DOC) and 11-deoxycortisol (compound S) as substrates, were performed. One incubation was carried out at various temperatures (25-38°C) and the other using a heat inhibition method. The results indicate a difference in the hydroxylation of 11-deoxycortisol to cortisol (compound F) and 11-deoxycorticosterone to corticosterone (compound B).
UR - http://www.scopus.com/inward/record.url?scp=0016139056&partnerID=8YFLogxK
U2 - 10.1016/0022-4731(74)90104-6
DO - 10.1016/0022-4731(74)90104-6
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AN - SCOPUS:0016139056
SN - 0022-4731
VL - 5
SP - 557
EP - 560
JO - Journal of Steroid Biochemistry
JF - Journal of Steroid Biochemistry
IS - 6
ER -