@article{d24ecfb096b84d8386b3e70f25da9b0a,
title = "Dietary enrichment with alpha-linolenic acid during pregnancy attenuates insulin resistance in adult offspring in mice",
abstract = "Objective: Our objective was to test the contribution of dietary enrichment in essential or saturated fatty acids, in normocaloric diets, on the lipid accumulation and insulin resistance in the adult offspring in a C57Bl6/J mice model. Methods: Pregnant mothers were fed normocaloric diets containing 6% fat enriched in essential fatty acids (EFA): alpha-linolenic (ALA-18:3, n-3), linoleic (LA-18:2, n-6), or saturated fatty acids (SFA). After a washing-out period with regular diet, the offspring received a high-fat diet before euthanization. Results: Adult mice fed maternal ALA showed lower body weight gain and lower liver fat accumulation, lower HOMA index and lower stearoyl-CoA desaturase (SCD1) activity than those fed maternal SFA. Conclusion: The results observed using this novel model suggest that ALA in maternal diet may have the potential to inhibit insulin resistance in adult offspring.",
keywords = "Alpha-linolenic acid, Dietary enrichment, Insulin resistance, Pregnancy",
author = "Hollander, {K. S.} and Brami, {C. Tempel} and Konikoff, {F. M.} and M. Fainaru and A. Leikin-Frenkel",
note = "Funding Information: This study was supported by the Moshe Ishai Center for the Investigation of Natural Food on the Quality of Human Health Grant, the Research Authority of Tel Aviv University and partial funding from the Minerva Foundation, Germany. Funding Information: Moshe Ishai Center for the Investigation of Natural Food on the Quality of Human Health Grant, the Research Authority of Tel Aviv University Grant and partial funding from the Minerva Foundation, Germany.",
year = "2014",
month = jul,
doi = "10.3109/13813455.2014.940352",
language = "אנגלית",
volume = "120",
pages = "99--111",
journal = "Archives of Physiology and Biochemistry",
issn = "1381-3455",
publisher = "Taylor and Francis Ltd.",
number = "3",
}