Dietary enrichment with alpha-linolenic acid during pregnancy attenuates insulin resistance in adult offspring in mice

K. S. Hollander, C. Tempel Brami, F. M. Konikoff, M. Fainaru, A. Leikin-Frenkel

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Our objective was to test the contribution of dietary enrichment in essential or saturated fatty acids, in normocaloric diets, on the lipid accumulation and insulin resistance in the adult offspring in a C57Bl6/J mice model. Methods: Pregnant mothers were fed normocaloric diets containing 6% fat enriched in essential fatty acids (EFA): alpha-linolenic (ALA-18:3, n-3), linoleic (LA-18:2, n-6), or saturated fatty acids (SFA). After a washing-out period with regular diet, the offspring received a high-fat diet before euthanization. Results: Adult mice fed maternal ALA showed lower body weight gain and lower liver fat accumulation, lower HOMA index and lower stearoyl-CoA desaturase (SCD1) activity than those fed maternal SFA. Conclusion: The results observed using this novel model suggest that ALA in maternal diet may have the potential to inhibit insulin resistance in adult offspring.

Original languageEnglish
Pages (from-to)99-111
Number of pages13
JournalArchives of Physiology and Biochemistry
Volume120
Issue number3
DOIs
StatePublished - Jul 2014

Keywords

  • Alpha-linolenic acid
  • Dietary enrichment
  • Insulin resistance
  • Pregnancy

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