TY - JOUR
T1 - Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort
AU - Braun, Tzipi
AU - Feng, Rui
AU - Amir, Amnon
AU - Levhar, Nina
AU - Shacham, Hila
AU - Mao, Ren
AU - Hadar, Rotem
AU - Toren, Itamar
AU - Algavi, Yadid
AU - Abu-Saad, Kathleen
AU - Zhuo, Shuoyu
AU - Efroni, Gilat
AU - Malik, Alona
AU - Picard, Orit
AU - Yavzori, Miri
AU - Agranovich, Bella
AU - Liu, Ta Chiang
AU - Stappenbeck, Thaddeus S.
AU - Denson, Lee
AU - Kalter-Leibovici, Ofra
AU - Gottlieb, Eyal
AU - Borenstein, Elhanan
AU - Elinav, Eran
AU - Chen, Minhu
AU - Ben-Horin, Shomron
AU - Haberman, Yael
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Crohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift. The Study Of Urban and Rural CD Evolution (SOURCE, n = 380) has considered diet-omics domains simultaneously to detect complex interactions and identify potential beneficial and pathogenic factors linked with rural-urban transition and CD. We characterize exposures, diet, ileal transcriptomics, metabolomics, and microbiome in newly diagnosed CD patients and controls in rural and urban China and Israel. We show that time spent by rural residents in urban environments is linked with changes in gut microbial composition and metabolomics, which mirror those seen in CD. Ileal transcriptomics highlights personal metabolic and immune gene expression modules, that are directly linked to potential protective dietary exposures (coffee, manganese, vitamin D), fecal metabolites, and the microbiome. Bacteria-associated metabolites are primarily linked with host immune modules, whereas diet-linked metabolites are associated with host epithelial metabolic functions.
AB - Crohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift. The Study Of Urban and Rural CD Evolution (SOURCE, n = 380) has considered diet-omics domains simultaneously to detect complex interactions and identify potential beneficial and pathogenic factors linked with rural-urban transition and CD. We characterize exposures, diet, ileal transcriptomics, metabolomics, and microbiome in newly diagnosed CD patients and controls in rural and urban China and Israel. We show that time spent by rural residents in urban environments is linked with changes in gut microbial composition and metabolomics, which mirror those seen in CD. Ileal transcriptomics highlights personal metabolic and immune gene expression modules, that are directly linked to potential protective dietary exposures (coffee, manganese, vitamin D), fecal metabolites, and the microbiome. Bacteria-associated metabolites are primarily linked with host immune modules, whereas diet-linked metabolites are associated with host epithelial metabolic functions.
UR - http://www.scopus.com/inward/record.url?scp=85192103404&partnerID=8YFLogxK
U2 - 10.1038/s41467-024-48106-6
DO - 10.1038/s41467-024-48106-6
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C2 - 38704361
AN - SCOPUS:85192103404
SN - 2041-1723
VL - 15
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 3764
ER -