Diastolic function as an early marker for systolic dysfunction and all-cause mortality among cancer patients

Joshua H. Arnold, Zach Rozenbaum, Aviram Hochstadt, Roni Rosen, Chen Sherez, Ayelet Sivan, Liat Mor, Yonatan Moshkovits, Ben Sadeh, Ofer Havakuk, Assi Milwidsky, Sivan Shamai, Svetlana Sirota Dorfman, Yaron Arbel, Yan Topilsky, Michal Laufer-Perl*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Increased survival among active cancer patients exposes a wide range of side effects, including cardiotoxicity, manifested by systolic dysfunction and associated with morbidity and mortality. Early diagnosis of subclinical function changes and cardiac damage is essential in the management of these patients. Diastolic dysfunction is considered common among cancer patients; however, its effect on systolic dysfunction or mortality is still unknown. Methods: Data were collected as part of the Israel Cardio-Oncology Registry, enrolling and prospectively following all patients evaluated in the cardio-oncology clinic in the Tel Aviv Sourasky Medical Center. All patients underwent echocardiographic examinations including evaluation of diastolic parameters and global longitudinal strain (GLS). Systolic dysfunction was defined as either an absolute reduction >10% in left ventricular ejection fraction to a value below 53% or GLS relative reduction >10% between the 1st and 3rd echocardiography examinations. Results: Overall, 190 active cancer patients were included, with a mean age of 58 ± 15 years and a female predominance (78%). During a median follow-up of 243 days (interquartile ranges [IQR]: 164-401 days), 62 (33%) patients developed systolic dysfunction. Over a median follow-up of 789 days (IQR: 521-968 days), 29 (15%) patients died. There were no significant differences in baseline cardiac risk factors between the groups. Using multivariate analysis, E/e′ lateral and e′ lateral emerged as significantly associated with systolic dysfunction development and all-cause mortality (P =.015). Conclusion: Among active cancer patients, evaluation of diastolic function may provide an early marker for the development of systolic dysfunction, as well as all-cause mortality.

Original languageEnglish
Pages (from-to)540-548
Number of pages9
Issue number4
StatePublished - Apr 2021


  • E/e′ lateral
  • GLS
  • cardiotoxicity
  • diastolic function
  • e′ lateral


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