Diastolic blood pressure is the first to rise in association with early subclinical obstructive sleep apnea: Lessons from periodic examination screening

Yehonatan Sharabi*, Alon Scope, Natasha Chorney, Itamar Grotto, Yaron Dagan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Background: Obstructive sleep apnea syndrome (OSAS) is associated with long-term cardiovascular morbidity. Little is known about these relations at early stages. We conducted a case-control study in which we analyzed the clinical characteristics of young adults who underwent a periodic health examination and were screened for, and eventually found to experience, OSAS. Methods: We identified 121 subjects newly diagnosed in a sleep study as having OSAS, and 229 matched control subjects in which screening for OSAS was negative. All had a medical interview, physical examination, and routine laboratory tests. Results: Subjects who had OSAS had a higher, body mass index (3-kg/m2 difference) and a higher diastolic c blood pressure (4-mm Hg difference) value, without elevation in systolic blood pressure. There was no metabolic difference (lipids profile and fasting glucose levels) between groups. Conclusions: Diastolic blood pressure is higher early in the course of OSAS. Long term follow-up may determine effects of prevention and early intervention in OSAS and associated hypertension.

Original languageEnglish
Pages (from-to)236-239
Number of pages4
JournalAmerican Journal of Hypertension
Volume16
Issue number3
DOIs
StatePublished - 1 Mar 2003
Externally publishedYes

Keywords

  • Blood pressure
  • Obstructive sleep apnea
  • Periodic examination
  • Screening

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