TY - JOUR
T1 - Diastolic blood pressure is the first to rise in association with early subclinical obstructive sleep apnea
T2 - Lessons from periodic examination screening
AU - Sharabi, Yehonatan
AU - Scope, Alon
AU - Chorney, Natasha
AU - Grotto, Itamar
AU - Dagan, Yaron
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Background: Obstructive sleep apnea syndrome (OSAS) is associated with long-term cardiovascular morbidity. Little is known about these relations at early stages. We conducted a case-control study in which we analyzed the clinical characteristics of young adults who underwent a periodic health examination and were screened for, and eventually found to experience, OSAS. Methods: We identified 121 subjects newly diagnosed in a sleep study as having OSAS, and 229 matched control subjects in which screening for OSAS was negative. All had a medical interview, physical examination, and routine laboratory tests. Results: Subjects who had OSAS had a higher, body mass index (3-kg/m2 difference) and a higher diastolic c blood pressure (4-mm Hg difference) value, without elevation in systolic blood pressure. There was no metabolic difference (lipids profile and fasting glucose levels) between groups. Conclusions: Diastolic blood pressure is higher early in the course of OSAS. Long term follow-up may determine effects of prevention and early intervention in OSAS and associated hypertension.
AB - Background: Obstructive sleep apnea syndrome (OSAS) is associated with long-term cardiovascular morbidity. Little is known about these relations at early stages. We conducted a case-control study in which we analyzed the clinical characteristics of young adults who underwent a periodic health examination and were screened for, and eventually found to experience, OSAS. Methods: We identified 121 subjects newly diagnosed in a sleep study as having OSAS, and 229 matched control subjects in which screening for OSAS was negative. All had a medical interview, physical examination, and routine laboratory tests. Results: Subjects who had OSAS had a higher, body mass index (3-kg/m2 difference) and a higher diastolic c blood pressure (4-mm Hg difference) value, without elevation in systolic blood pressure. There was no metabolic difference (lipids profile and fasting glucose levels) between groups. Conclusions: Diastolic blood pressure is higher early in the course of OSAS. Long term follow-up may determine effects of prevention and early intervention in OSAS and associated hypertension.
KW - Blood pressure
KW - Obstructive sleep apnea
KW - Periodic examination
KW - Screening
UR - http://www.scopus.com/inward/record.url?scp=0037336456&partnerID=8YFLogxK
U2 - 10.1016/S0895-7061(02)03250-8
DO - 10.1016/S0895-7061(02)03250-8
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C2 - 12620704
AN - SCOPUS:0037336456
SN - 0895-7061
VL - 16
SP - 236
EP - 239
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 3
ER -