TY - JOUR
T1 - Diameters of single-walled carbon nanotubes (SWCNTs) and related nanochemistry and nanobiology
AU - Ma, Jie
AU - Wang, Jian Nong
AU - Tsai, Chung Jung
AU - Nussinov, Ruth
AU - Ma, Buyong
N1 - Funding Information:
Acknowledgements This project has been funded in whole or in part with Federal Funds from the NCI, National Institutes of Health, under contract number HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does the mention of trade names, commercial products, or organizations implies endorsement by the U.S. Government. This research was supported (in part) by the Intramural Research Program of the NIH, NCI, Center for Cancer Research. Prof. Jian-Nong Wang is thankful to the support from the National Natural Science Foundation of China (Grant No. 50871067) and the fund for the National 863 Project of 2007AA05Z128 from the Ministry of Science and Technology of China.
PY - 2010/2
Y1 - 2010/2
N2 - We reviewed and examined recent progresses related to the nanochemistry and nanobiology of signal-walled carbon nanotubes (SWCNTs), focusing on the diameters of SWCNTs and how the diameters affect the interactions of SWCNT with protein and DNA, which underlay more complex biological responses. The diameters of SWCNTs are closely related to the electronic structure and surface chemistry of SWCNTs, and subsequently affect the interaction of SWCNTs with membrane, protein, and DNA. The surfaces of SWCNT with smaller diameters are more polar, and these with large diameters are more hydrophobic. The preference of SWCNT to interact with Trp/Phe/Met residues indicates it is possible that SWCNT may interfere with normal protein-protein interactions. SWCNT-DNA interactions often change DNA conformation. Besides the promising future of using SWCNTs as delivering nanomaterial, thermal therapy, and other biological applications, we should thoroughly examine the possible effects of carbon nanotube on interrupting normal protein-protein interaction network and other genetic effects at the cellular level.
AB - We reviewed and examined recent progresses related to the nanochemistry and nanobiology of signal-walled carbon nanotubes (SWCNTs), focusing on the diameters of SWCNTs and how the diameters affect the interactions of SWCNT with protein and DNA, which underlay more complex biological responses. The diameters of SWCNTs are closely related to the electronic structure and surface chemistry of SWCNTs, and subsequently affect the interaction of SWCNTs with membrane, protein, and DNA. The surfaces of SWCNT with smaller diameters are more polar, and these with large diameters are more hydrophobic. The preference of SWCNT to interact with Trp/Phe/Met residues indicates it is possible that SWCNT may interfere with normal protein-protein interactions. SWCNT-DNA interactions often change DNA conformation. Besides the promising future of using SWCNTs as delivering nanomaterial, thermal therapy, and other biological applications, we should thoroughly examine the possible effects of carbon nanotube on interrupting normal protein-protein interaction network and other genetic effects at the cellular level.
KW - Cancer
KW - Carbon nanotube (CNT)
KW - DNA
KW - Nanobiology
KW - Protein
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=76749165755&partnerID=8YFLogxK
U2 - 10.1007/s11706-010-0001-8
DO - 10.1007/s11706-010-0001-8
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AN - SCOPUS:76749165755
SN - 1863-1703
VL - 4
SP - 17
EP - 28
JO - Signal, Image and Video Processing
JF - Signal, Image and Video Processing
IS - 1
ER -
