Diagnostic value of AgNOR staining in thyroid cytology

Lea Shechtman; Rumelia Koren; Ada Horowitz; Itschak Shechtman; Marisa Halpern; Rivka Gal

Diagnostic value of AgNOR staining in thyroid cytology

Lea Shechtman, Rumelia Koren, Ada Horowitz, Itschak Shechtman, Marisa Halpern, Rivka Gal^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To determine the value of the argyrophil nucleolar organizer region (AgNOR) technique on scrape cytology of thyroid lesions. STUDY DESIGN: AgNOR counts were evaluated in smears of 70 thyroid lesions that were sent for frozen section and included 15 cases of follicular adenoma, 10 cases of follicular carcinoma, 13 cases of papillary carcinoma, 23 cases of nodular goiter and 9 cases of Hashimoto's thyroiditis. Forty-one slides out of 70 were freshly prepared, and 29 slides had been previously stained with hematoxylin and eosin and then destained with alcohol. The number of AgNOR dots was recorded for 50 cells, and the mean number was calculated. RESULTS: The mean AgNOR counts were statistically significantly higher in malignant lesions in comparison to benign lesions. CONCLUSION: AgNOR staining could be of use in cytologic material from thyroid lesions.

Original language	English
Pages (from-to)	187-191
Number of pages	5
Journal	Analytical and Quantitative Cytology and Histology
Volume	20
Issue number	3
State	Published - Jun 1998

Keywords

Nucleolus organizer region
Thyroid diseases
Thyroid neoplasms

Cite this

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title = "Diagnostic value of AgNOR staining in thyroid cytology",

abstract = "OBJECTIVE: To determine the value of the argyrophil nucleolar organizer region (AgNOR) technique on scrape cytology of thyroid lesions. STUDY DESIGN: AgNOR counts were evaluated in smears of 70 thyroid lesions that were sent for frozen section and included 15 cases of follicular adenoma, 10 cases of follicular carcinoma, 13 cases of papillary carcinoma, 23 cases of nodular goiter and 9 cases of Hashimoto's thyroiditis. Forty-one slides out of 70 were freshly prepared, and 29 slides had been previously stained with hematoxylin and eosin and then destained with alcohol. The number of AgNOR dots was recorded for 50 cells, and the mean number was calculated. RESULTS: The mean AgNOR counts were statistically significantly higher in malignant lesions in comparison to benign lesions. CONCLUSION: AgNOR staining could be of use in cytologic material from thyroid lesions.",

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author = "Lea Shechtman and Rumelia Koren and Ada Horowitz and Itschak Shechtman and Marisa Halpern and Rivka Gal",

year = "1998",

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T1 - Diagnostic value of AgNOR staining in thyroid cytology

AU - Shechtman, Lea

AU - Koren, Rumelia

AU - Horowitz, Ada

AU - Shechtman, Itschak

AU - Halpern, Marisa

AU - Gal, Rivka

PY - 1998/6

Y1 - 1998/6

N2 - OBJECTIVE: To determine the value of the argyrophil nucleolar organizer region (AgNOR) technique on scrape cytology of thyroid lesions. STUDY DESIGN: AgNOR counts were evaluated in smears of 70 thyroid lesions that were sent for frozen section and included 15 cases of follicular adenoma, 10 cases of follicular carcinoma, 13 cases of papillary carcinoma, 23 cases of nodular goiter and 9 cases of Hashimoto's thyroiditis. Forty-one slides out of 70 were freshly prepared, and 29 slides had been previously stained with hematoxylin and eosin and then destained with alcohol. The number of AgNOR dots was recorded for 50 cells, and the mean number was calculated. RESULTS: The mean AgNOR counts were statistically significantly higher in malignant lesions in comparison to benign lesions. CONCLUSION: AgNOR staining could be of use in cytologic material from thyroid lesions.

AB - OBJECTIVE: To determine the value of the argyrophil nucleolar organizer region (AgNOR) technique on scrape cytology of thyroid lesions. STUDY DESIGN: AgNOR counts were evaluated in smears of 70 thyroid lesions that were sent for frozen section and included 15 cases of follicular adenoma, 10 cases of follicular carcinoma, 13 cases of papillary carcinoma, 23 cases of nodular goiter and 9 cases of Hashimoto's thyroiditis. Forty-one slides out of 70 were freshly prepared, and 29 slides had been previously stained with hematoxylin and eosin and then destained with alcohol. The number of AgNOR dots was recorded for 50 cells, and the mean number was calculated. RESULTS: The mean AgNOR counts were statistically significantly higher in malignant lesions in comparison to benign lesions. CONCLUSION: AgNOR staining could be of use in cytologic material from thyroid lesions.

KW - Nucleolus organizer region

KW - Thyroid diseases

KW - Thyroid neoplasms

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JO - Analytical and Quantitative Cytology and Histology

JF - Analytical and Quantitative Cytology and Histology

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Diagnostic value of AgNOR staining in thyroid cytology

Abstract

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