Diagnostic value of AgNOR staining in thyroid cytology

Lea Shechtman, Rumelia Koren, Ada Horowitz, Itschak Shechtman, Marisa Halpern, Rivka Gal*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To determine the value of the argyrophil nucleolar organizer region (AgNOR) technique on scrape cytology of thyroid lesions. STUDY DESIGN: AgNOR counts were evaluated in smears of 70 thyroid lesions that were sent for frozen section and included 15 cases of follicular adenoma, 10 cases of follicular carcinoma, 13 cases of papillary carcinoma, 23 cases of nodular goiter and 9 cases of Hashimoto's thyroiditis. Forty-one slides out of 70 were freshly prepared, and 29 slides had been previously stained with hematoxylin and eosin and then destained with alcohol. The number of AgNOR dots was recorded for 50 cells, and the mean number was calculated. RESULTS: The mean AgNOR counts were statistically significantly higher in malignant lesions in comparison to benign lesions. CONCLUSION: AgNOR staining could be of use in cytologic material from thyroid lesions.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalAnalytical and Quantitative Cytology and Histology
Issue number3
StatePublished - Jun 1998


  • Nucleolus organizer region
  • Thyroid diseases
  • Thyroid neoplasms


Dive into the research topics of 'Diagnostic value of AgNOR staining in thyroid cytology'. Together they form a unique fingerprint.

Cite this