Diagnostic efficacy of positron emission computerized tomography scans in suspicious laryngeal findings postorgan preservation treatment

Anton Warshavsky; Ariel Holan; Nidal Muhanna; Yael Oestraicher; Yuval Nachalon; Liyona Kampel; Narin Nard-Carmel; Hen Chaushu; Udi Shapira; Omer Ungar; Orit Gutfeld; Inna Ospovat; Yasmin Natan Oz; Einat Even-Sapir; Gilad Horowitz

doi:10.1002/hed.27227

Diagnostic efficacy of positron emission computerized tomography scans in suspicious laryngeal findings postorgan preservation treatment

Anton Warshavsky^*, Ariel Holan, Nidal Muhanna, Yael Oestraicher, Yuval Nachalon, Liyona Kampel, Narin Nard-Carmel, Hen Chaushu, Udi Shapira, Omer Ungar, Orit Gutfeld, Inna Ospovat, Yasmin Natan Oz, Einat Even-Sapir, Gilad Horowitz

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Larynx preservation protocols (LPP) for glottic primary squamous cell carcinoma has gained popularity worldwide. Direct laryngoscopy (DL) with biopsy is mandated when recurrence is suspected. The efficacy of 18Fluoro-deoxy-glucose positron emission computerized tomography (PET-CT) as alternative first-line diagnostic investigation in suspected recurrence was evaluated. Methods: A retrospective study of patients with suspicious fiber-optic findings at more than 12 weeks after LPP. Sensitivity, specificity, and the negative predictive value (NPV) of DL and PET-CT were compared. Results: Seventy-two patients presenting 105 cases of suspicious events were included in this study. Fifty-two events were initially investigated by DL and 53 events by PET-CT. The sensitivity of DL and PET-CT was 56.25% and 100%, respectively. The NPV was 84% for DL and 100% for PET-CT (p = 0.015). Conclusion: Negative PET scans after LPP are highly accurate in ruling out recurrent/persistent disease and may spare the patient from negative biopsies.

Original language	English
Pages (from-to)	207-211
Number of pages	5
Journal	Head and Neck
Volume	45
Issue number	1
DOIs	https://doi.org/10.1002/hed.27227
State	Published - Jan 2023

Keywords

direct laryngoscopy
follow-up
larynx
positron emission tomography scan

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.27227

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Warshavsky, A., Holan, A., Muhanna, N., Oestraicher, Y., Nachalon, Y., Kampel, L., Nard-Carmel, N., Chaushu, H., Shapira, U., Ungar, O., Gutfeld, O., Ospovat, I., Oz, Y. N., Even-Sapir, E., & Horowitz, G. (2023). Diagnostic efficacy of positron emission computerized tomography scans in suspicious laryngeal findings postorgan preservation treatment. Head and Neck, 45(1), 207-211. https://doi.org/10.1002/hed.27227

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title = "Diagnostic efficacy of positron emission computerized tomography scans in suspicious laryngeal findings postorgan preservation treatment",

abstract = "Background: Larynx preservation protocols (LPP) for glottic primary squamous cell carcinoma has gained popularity worldwide. Direct laryngoscopy (DL) with biopsy is mandated when recurrence is suspected. The efficacy of 18Fluoro-deoxy-glucose positron emission computerized tomography (PET-CT) as alternative first-line diagnostic investigation in suspected recurrence was evaluated. Methods: A retrospective study of patients with suspicious fiber-optic findings at more than 12 weeks after LPP. Sensitivity, specificity, and the negative predictive value (NPV) of DL and PET-CT were compared. Results: Seventy-two patients presenting 105 cases of suspicious events were included in this study. Fifty-two events were initially investigated by DL and 53 events by PET-CT. The sensitivity of DL and PET-CT was 56.25% and 100%, respectively. The NPV was 84% for DL and 100% for PET-CT (p = 0.015). Conclusion: Negative PET scans after LPP are highly accurate in ruling out recurrent/persistent disease and may spare the patient from negative biopsies.",

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author = "Anton Warshavsky and Ariel Holan and Nidal Muhanna and Yael Oestraicher and Yuval Nachalon and Liyona Kampel and Narin Nard-Carmel and Hen Chaushu and Udi Shapira and Omer Ungar and Orit Gutfeld and Inna Ospovat and Oz, {Yasmin Natan} and Einat Even-Sapir and Gilad Horowitz",

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doi = "10.1002/hed.27227",

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Warshavsky, A, Holan, A, Muhanna, N, Oestraicher, Y, Nachalon, Y, Kampel, L, Nard-Carmel, N, Chaushu, H, Shapira, U, Ungar, O, Gutfeld, O, Ospovat, I, Oz, YN, Even-Sapir, E & Horowitz, G 2023, 'Diagnostic efficacy of positron emission computerized tomography scans in suspicious laryngeal findings postorgan preservation treatment', Head and Neck, vol. 45, no. 1, pp. 207-211. https://doi.org/10.1002/hed.27227

TY - JOUR

T1 - Diagnostic efficacy of positron emission computerized tomography scans in suspicious laryngeal findings postorgan preservation treatment

AU - Warshavsky, Anton

AU - Holan, Ariel

AU - Muhanna, Nidal

AU - Oestraicher, Yael

AU - Nachalon, Yuval

AU - Kampel, Liyona

AU - Nard-Carmel, Narin

AU - Chaushu, Hen

AU - Shapira, Udi

AU - Ungar, Omer

AU - Gutfeld, Orit

AU - Ospovat, Inna

AU - Oz, Yasmin Natan

AU - Even-Sapir, Einat

AU - Horowitz, Gilad

PY - 2023/1

Y1 - 2023/1

N2 - Background: Larynx preservation protocols (LPP) for glottic primary squamous cell carcinoma has gained popularity worldwide. Direct laryngoscopy (DL) with biopsy is mandated when recurrence is suspected. The efficacy of 18Fluoro-deoxy-glucose positron emission computerized tomography (PET-CT) as alternative first-line diagnostic investigation in suspected recurrence was evaluated. Methods: A retrospective study of patients with suspicious fiber-optic findings at more than 12 weeks after LPP. Sensitivity, specificity, and the negative predictive value (NPV) of DL and PET-CT were compared. Results: Seventy-two patients presenting 105 cases of suspicious events were included in this study. Fifty-two events were initially investigated by DL and 53 events by PET-CT. The sensitivity of DL and PET-CT was 56.25% and 100%, respectively. The NPV was 84% for DL and 100% for PET-CT (p = 0.015). Conclusion: Negative PET scans after LPP are highly accurate in ruling out recurrent/persistent disease and may spare the patient from negative biopsies.

AB - Background: Larynx preservation protocols (LPP) for glottic primary squamous cell carcinoma has gained popularity worldwide. Direct laryngoscopy (DL) with biopsy is mandated when recurrence is suspected. The efficacy of 18Fluoro-deoxy-glucose positron emission computerized tomography (PET-CT) as alternative first-line diagnostic investigation in suspected recurrence was evaluated. Methods: A retrospective study of patients with suspicious fiber-optic findings at more than 12 weeks after LPP. Sensitivity, specificity, and the negative predictive value (NPV) of DL and PET-CT were compared. Results: Seventy-two patients presenting 105 cases of suspicious events were included in this study. Fifty-two events were initially investigated by DL and 53 events by PET-CT. The sensitivity of DL and PET-CT was 56.25% and 100%, respectively. The NPV was 84% for DL and 100% for PET-CT (p = 0.015). Conclusion: Negative PET scans after LPP are highly accurate in ruling out recurrent/persistent disease and may spare the patient from negative biopsies.

KW - direct laryngoscopy

KW - follow-up

KW - larynx

KW - positron emission tomography scan

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SN - 1043-3074

VL - 45

SP - 207

EP - 211

JO - Head and Neck

JF - Head and Neck

IS - 1

ER -

Diagnostic efficacy of positron emission computerized tomography scans in suspicious laryngeal findings postorgan preservation treatment

Abstract

Keywords

UN SDGs

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