DIAGNOSTIK DER KORONAREN HERZKRANKHEIT. MOGLICHKEITEN UND GRENZEN VON NICHTINVASIVEN METHODEN (EKG, THALLIUM-PERFUSIONS-SZINTIGRAPHIE, RADIONUKLID-ANGIOGRAPHIE)

Translated title of the contribution: Diagnosis of coronary artery disease: Value and limitations of non-invasive methods ECG, thallium perfusion scintigraphy, radionuclide angiography)

M. Pfisterer, D. Gordon, A. Battler

Research output: Contribution to journalArticlepeer-review

Abstract

In order to compare the three non-invasive exercise tests Ecg, Thallium myocardial perfusion imaging and radionuclide angiography in the diagnosis of coronary artery disease, the results of these tests in a consecutive series of 30 patients and 14 controls were analyzed. In all 88 symptom-limited exercise tests a significantly higher double product (heart rate x systolic blood pressure, mm Hg/min) was reached on a treadmill test (for Ecg and Thallium scintigraphy) as compared to the supine bicycle ergometer exercise (for radionuclide angiography: 243 ± 61.1 vs. 215.2 ± 46.5 102 (p < 0.01). considering all 132 diagnostic tests the overall sensitivity for rest/exercise Ecg was 67%, for Thallium scans 77%, for both combined 83% and for the ejection fraction response to exercise determined by radionuclide angiography 97%. If only the exercise response was considered, the corresponding sensitivity values were 60% (Ecg), 47% (Thallium scans), 70% (both tests combined) and 97% (radionuclide angiography). The specificity for coronary artery disease was determined to be 79% for Ecg, 86% for Thallium scintigraphy, 64% for Ecg/Thallium scans and 71% for radionuclide angiography. The most common reasons for a false-positive result in all tests was found to be the diagnosis of cardiomyopathy, whereas most false-negative results were seen in patients with single vessel right coronary artery disease. Based on these results, the clinical implications of the three non-invasive tests in the diagnosis of coronary artery disease are discussed.

Translated title of the contributionDiagnosis of coronary artery disease: Value and limitations of non-invasive methods ECG, thallium perfusion scintigraphy, radionuclide angiography)
Original languageGerman
Pages (from-to)748-753
Number of pages6
JournalZeitschrift fur Kardiologie
Volume68
Issue number11
StatePublished - 1979
Externally publishedYes

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