TY - JOUR
T1 - Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients
T2 - a refined classification from the European society for blood and marrow transplantation (EBMT)
AU - Mohty, Mohamad
AU - Malard, Florent
AU - Alaskar, Ahmed S.
AU - Aljurf, Mahmoud
AU - Arat, Mutlu
AU - Bader, Peter
AU - Baron, Frederic
AU - Bazarbachi, Ali
AU - Blaise, Didier
AU - Brissot, Eolia
AU - Ciceri, Fabio
AU - Corbacioglu, Selim
AU - Dalle, Jean Hugues
AU - Dignan, Fiona
AU - Huynh, Anne
AU - Kenyon, Michelle
AU - Nagler, Arnon
AU - Pagliuca, Antonio
AU - Perić, Zinaida
AU - Richardson, Paul G.
AU - Ruggeri, Annalisa
AU - Ruutu, Tapani
AU - Yakoub-Agha, Ibrahim
AU - Duarte, Rafael F.
AU - Carreras, Enric
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2023/7
Y1 - 2023/7
N2 - Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). A new definition for diagnosis, and a severity grading system for SOS/VOD in adult patients, was reported a few years ago on behalf of the European Society for Blood and Marrow Transplantation (EBMT). The aim of this work is to update knowledge regarding diagnosis and severity assessment of SOS/VOD in adult patients, and also its pathophysiology and treatment. In particular, we now propose to refine the previous classification and distinguish probable, clinical and proven SOS/VOD at diagnosis. We also provide an accurate definition of multiorgan dysfunction (MOD) for SOS/VOD severity grading based on Sequential Organ Failure Assessment (SOFA) score.
AB - Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). A new definition for diagnosis, and a severity grading system for SOS/VOD in adult patients, was reported a few years ago on behalf of the European Society for Blood and Marrow Transplantation (EBMT). The aim of this work is to update knowledge regarding diagnosis and severity assessment of SOS/VOD in adult patients, and also its pathophysiology and treatment. In particular, we now propose to refine the previous classification and distinguish probable, clinical and proven SOS/VOD at diagnosis. We also provide an accurate definition of multiorgan dysfunction (MOD) for SOS/VOD severity grading based on Sequential Organ Failure Assessment (SOFA) score.
UR - https://www.scopus.com/pages/publications/85153340348
U2 - 10.1038/s41409-023-01992-8
DO - 10.1038/s41409-023-01992-8
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C2 - 37095231
AN - SCOPUS:85153340348
SN - 0268-3369
VL - 58
SP - 749
EP - 754
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 7
ER -